Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 15/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | BCL3 | P20749 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4224516 | 0.97 | HDAC1 (0.39) | HDAC1HDAC3HDAC2HDAC8HDAC10 | |
| SCHEMBL4234525 | 0.87 | HDAC1 (0.41) | HDAC1HDAC3HDAC2HDAC8HDAC10 | |
| SCHEMBL4228671 | 0.87 | HDAC1 (0.41) | HDAC1HDAC3HDAC2HDAC8HDAC10 | |
| SCHEMBL4233200 | 0.87 | HDAC3 (0.41) | HDAC1HDAC3HDAC2HDAC8HDAC10 | |
| SCHEMBL4220624 | 0.86 | CD274 (0.38) | BCL3POLB | |
| SCHEMBL2385365 | 0.85 | POLB (0.43) | HDAC1HDAC3HDAC2HDAC8HDAC10 | |
| SCHEMBL4233251 | 0.85 | HDAC1 (0.39) | HDAC1HDAC3HDAC2HDAC8HDAC10 | |
| SCHEMBL2383602 | 0.85 | MAPT (0.43) | HDAC1HDAC3HDAC2HDAC8HDAC10 | |
| SCHEMBL2386711 | 0.85 | EPHX2 (0.49) | HDAC1HDAC3HDAC2HDAC8HDAC10 | |
| SCHEMBL4379718 | 0.85 | EPHX2 (0.42) | HDAC1HDAC3HDAC2HDAC8HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2133339-A1 | NOVEL (2-AMINOPHENYL)PYRIDINECARBOXAMIDE DERIVATIVE HAVING UREA STRUCTURE | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-16 | — | — | EP | disclosed |