Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | BCL3 | P20749 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4222628 | 0.98 | HDAC1 (0.38) | HDAC1HDAC3HDAC8PIK3CAHDAC2 | |
| SCHEMBL1497007 | 0.93 | ROCK2 (0.37) | HDAC3HDAC2EPHX2ROCK2AKT1 | |
| SCHEMBL4233200 | 0.89 | HDAC3 (0.41) | HDAC1HDAC3HDAC8PIK3CAHDAC2 | |
| SCHEMBL2474116 | 0.89 | HDAC1 (0.48) | HDAC1HDAC3HDAC8PIK3CAHDAC2 | |
| SCHEMBL1497095 | 0.89 | AKT1 (0.35) | HDAC1HDAC3HDAC2EPHX2CYP1A2 | |
| SCHEMBL2386711 | 0.88 | EPHX2 (0.49) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL4364256 | 0.87 | EPHX2 (0.44) | HDAC1EPHX2KCNH2 | |
| SCHEMBL4235025 | 0.87 | CASR (0.46) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL3230179 | 0.87 | JAK2 (0.38) | EPHX2CYP1A2POLBCYP3A4CYP2C9 | |
| SCHEMBL4222636 | 0.87 | RAB9A (0.44) | HDAC1HDAC3HDAC8PIK3CAHDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2133339-A1 | NOVEL (2-AMINOPHENYL)PYRIDINECARBOXAMIDE DERIVATIVE HAVING UREA STRUCTURE | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-16 | — | — | EP | disclosed |