Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 9/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | TP53 | P04637 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4229327 | 0.88 | LMNA (0.39) | LMNAMAPTTP53MEN1KMT2A | |
| SCHEMBL2384055 | 0.82 | HDAC3 (0.41) | LMNAMEN1KMT2ANPC1RAB9A | |
| SCHEMBL4219387 | 0.81 | HDAC3 (0.47) | LMNAMAPTHDAC3HDAC1HDAC8 | |
| SCHEMBL4229729 | 0.81 | HDAC1 (0.41) | LMNAMAPTTP53MEN1KMT2A | |
| SCHEMBL2385434 | 0.81 | NPC1 (0.45) | LMNAMAPTMEN1KMT2ANPC1 | |
| SCHEMBL4225186 | 0.81 | HDAC3 (0.46) | NPC1SMN1; SMN2HDAC3HDAC1HDAC8 | |
| SCHEMBL2384921 | 0.80 | HDAC1 (0.51) | LMNAMAPTTP53MEN1KMT2A | |
| SCHEMBL4229478 | 0.80 | HDAC3 (0.41) | MAPTTP53MEN1KMT2AALDH1A1 | |
| SCHEMBL2386015 | 0.80 | HDAC3 (0.43) | HDAC3HDAC1HDAC8UTS2R | |
| SCHEMBL4227992 | 0.80 | HDAC3 (0.42) | MAPTTP53MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2133339-A1 | NOVEL (2-AMINOPHENYL)PYRIDINECARBOXAMIDE DERIVATIVE HAVING UREA STRUCTURE | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-16 | — | — | EP | disclosed |