Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4235669 | 0.91 | CHRM1 (0.55) | CHRM1CHRM4CHRM5SIGMAR1SMN1; SMN2 | |
| SCHEMBL4226945 | 0.78 | CHRM1 (0.45) | CHRM1CHRM4CHRM5CHRM2DRD2 | |
| SCHEMBL4051360 | 0.78 | SIGMAR1 (0.47) | CHRM1CHRM4CHRM5SIGMAR1CHRM2 | |
| SCHEMBL4231625 | 0.77 | CHRM1 (0.53) | CHRM1CHRM4CHRM5SIGMAR1 | |
| SCHEMBL4049616 | 0.76 | SIGMAR1 (0.49) | CHRM1CHRM4CHRM5SIGMAR1CHRM2 | |
| SCHEMBL1554091 | 0.73 | CHRM1 (0.49) | CHRM1CHRM4CHRM5SIGMAR1CHRM2 | |
| SCHEMBL4230607 | 0.69 | CHRM1 (0.65) | CHRM1CHRM4CHRM5SIGMAR1SMN1; SMN2 | |
| SCHEMBL4055943 | 0.68 | CHRM1 (1.00) | CHRM1CHRM4CHRM5SIGMAR1SMN1; SMN2 | |
| SCHEMBL2406403 | 0.67 | SIGMAR1 (0.70) | SIGMAR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4049143 | 0.67 | CHRM1 (0.35) | CHRM1CHRM4CHRM5ALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106534-A1 | NOVEL HETEROCYCLIC CARBOXAMIDES AS M1 AGONISTS | H. LUNDBECK A/S (DK) | 2009-09-03 | — | — | WO | claimed |
| WO-2009106534-A1 | NOVEL HETEROCYCLIC CARBOXAMIDES AS M1 AGONISTS | H. LUNDBECK A/S (DK) | 2009-09-03 | — | — | WO | disclosed |