Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4223386 | 0.94 | GCGR (0.45) | GCGRALDH1A1HTTGAAMAPT | |
| SCHEMBL949686 | 0.87 | MAPT (0.45) | GCGRALDH1A1HTTGAAMAPT | |
| SCHEMBL950735 | 0.86 | GCGR (0.42) | GCGRALDH1A1HTTGAAMAPT | |
| SCHEMBL4433512 | 0.81 | MAPT (0.46) | GCGRALDH1A1HTTGAAMAPT | |
| SCHEMBL4224018 | 0.81 | GCGR (0.42) | GCGRALDH1A1HTTGAAMAPT | |
| SCHEMBL4443509 | 0.80 | GCGR (0.45) | GCGRALDH1A1HTTGAAMAPT | |
| SCHEMBL950810 | 0.77 | ALDH1A1 (0.56) | GCGRALDH1A1HTTGAAMAPT | |
| SCHEMBL950280 | 0.76 | ALDH1A1 (0.55) | GCGRALDH1A1HTTGAAMAPT | |
| SCHEMBL949981 | 0.74 | ALDH1A1 (0.55) | GCGRALDH1A1HTTGAAMAPT | |
| SCHEMBL4230837 | 0.74 | GCGR (0.44) | GCGRALDH1A1HTTGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090062360-A1 | Compounds Which Inhibit the Glycine Transporter and Uses Thereof | GLAXO GROUP LIMITED (GB) | 2009-03-05 | — | — | US | disclosed |
| EP-1994010-A1 | COMPOUNDS WHICH INHIBIT THE GLYCINE TRANSPORTER AND USES THEREOF | GLAXO GROUP LIMITED (GB) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007104775-A1 | COMPOUNDS WHICH INHIBIT THE GLYCINE TRANSPORTER AND USES THEREOF | GLAXO GROUP LIMITED (GB) | 2007-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062360-A1 | Compounds Which Inhibit the Glycine Transporter and Uses Thereof | SLC18A2, SLC1A2, SLC1A1 | GCGR 571/4885ALDH1A1 974/4885HTT 358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.