Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 10/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL950735 | 0.94 | GCGR (0.42) | GCGRALDH1A1HTTCYP2C9PSEN1 | |
| SCHEMBL4229216 | 0.86 | GCGR (0.47) | GCGRALDH1A1HTTMAPTTP53 | |
| SCHEMBL4223386 | 0.85 | GCGR (0.45) | GCGRALDH1A1HTTMAPTTP53 | |
| SCHEMBL4230837 | 0.81 | GCGR (0.44) | GCGRALDH1A1HTTMAPTTP53 | |
| SCHEMBL4230649 | 0.80 | GCGR (0.42) | GCGRALDH1A1HTTMAPTTP53 | |
| SCHEMBL950810 | 0.75 | ALDH1A1 (0.56) | GCGRALDH1A1HTTMAPTTP53 | |
| SCHEMBL950280 | 0.74 | ALDH1A1 (0.55) | GCGRALDH1A1HTTMAPTTP53 | |
| SCHEMBL950281 | 0.72 | GCGR (0.37) | GCGRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4598474 | 0.72 | MAPT (0.39) | GCGRALDH1A1HTTMAPTTP53 | |
| SCHEMBL949981 | 0.70 | ALDH1A1 (0.55) | GCGRALDH1A1HTTMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121625-A1 | GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS | Glaxo Group Limited (GB) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008092879-A1 | GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2008-08-07 | — | — | WO | disclosed |