Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.45 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4238264 | 0.83 | PDE4B (0.36) | PDE4APDE4BPDE4CPDE4DCECR2 | |
| SCHEMBL4061817 | 0.78 | PDE4A (0.36) | PDE4APDE4BPDE4CPDE4DCECR2 | |
| SCHEMBL4229923 | 0.78 | — | — | |
| SCHEMBL4058080 | 0.76 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL2863687 | 0.73 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL11825573 | 0.73 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL4232540 | 0.73 | AHR (0.39) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| SCHEMBL6607682 | 0.72 | PDE4D (0.46) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL11119613 | 0.72 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL6618935 | 0.72 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009115874-A2 | NOVEL HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009115874-A2 | NOVEL HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-09-24 | — | — | WO | disclosed |