Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.36 |
| ▸ | PDE4A | P27815 | 6/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.36 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4230852 | 0.83 | PDE4A (0.45) | PDE4BPDE4APDE4CPDE4DCECR2 | |
| SCHEMBL6601910 | 0.74 | LMNA (0.41) | PDE4BPDE4APDE4CPDE4DABCB1 | |
| SCHEMBL6601911 | 0.74 | LMNA (0.41) | PDE4BPDE4APDE4CPDE4DABCB1 | |
| SCHEMBL6601913 | 0.74 | LMNA (0.41) | PDE4BPDE4APDE4CPDE4DABCB1 | |
| SCHEMBL4229923 | 0.74 | — | — | |
| SCHEMBL8327534 | 0.71 | PDE4B (0.35) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL13350327 | 0.71 | PDE4B (0.35) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL6867958 | 0.68 | PDE4B (0.32) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6867957 | 0.68 | PDE4B (0.32) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6867953 | 0.68 | PDE4B (0.32) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009115874-A2 | NOVEL HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-09-24 | — | — | WO | disclosed |