Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD4 | P21917 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | GMNN | O75496 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4225165 | 0.91 | MKNK2 (0.35) | SSTR5CYP3A4DRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL4223228 | 0.87 | SSTR5 (0.36) | SSTR5CYP3A4DRD2DRD4DRD3 | |
| SCHEMBL4230353 | 0.85 | SSTR5 (0.39) | SSTR5DRD2DRD4DRD3MKNK1 | |
| SCHEMBL4233683 | 0.85 | SSTR5 (0.37) | SSTR5CYP3A4DRD2DRD4DRD3 | |
| SCHEMBL4237977 | 0.85 | SSTR5 (0.39) | SSTR5DRD2DRD4DRD3MKNK1 | |
| SCHEMBL4232812 | 0.83 | SSTR5 (0.38) | SSTR5DRD2DRD4DRD3MKNK1 | |
| SCHEMBL4233365 | 0.83 | SSTR5 (0.39) | SSTR5DRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL4231315 | 0.82 | SSTR5 (0.43) | SSTR5ALDH1A1HCRTR1HCRTR2NPSR1 | |
| SCHEMBL4234813 | 0.82 | SSTR5 (0.40) | SSTR5CYP3A4DRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL4232796 | 0.78 | PAX8 (0.35) | SSTR5CYP3A4DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001867-B1 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-07-01 | — | — | EP | disclosed |