Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 3/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | CIT | O14578 | 7/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.40 |
| ▸ | CCNK | O75909 | 2/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | PRKACA | P17612 | 2/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.37 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23004035 | 0.82 | PRKCI (0.47) | PRKCIAXLCITNUDT1CCNK | |
| SCHEMBL1439912 | 0.78 | PRKCI (0.50) | PRKCIAXLCITNUDT1CCNK | |
| SCHEMBL23353587 | 0.78 | PRKCI (0.46) | PRKCIAXLCITNUDT1CCNK | |
| SCHEMBL84365 | 0.75 | PRKCI (0.53) | PRKCIAXLCITNUDT1CCNK | |
| SCHEMBL19565806 | 0.74 | LMNA (0.43) | — | |
| SCHEMBL20309049 | 0.74 | LMNA (0.43) | — | |
| SCHEMBL19120814 | 0.74 | GPR84 (0.41) | — | |
| SCHEMBL28887458 | 0.72 | ADA (0.44) | KDR | |
| SCHEMBL23021726 | 0.72 | PRKCI (0.50) | PRKCIAXLCITNUDT1JAK2 | |
| SCHEMBL24492983 | 0.72 | PRKCI (0.50) | PRKCIAXLCITNUDT1CCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2109611-A1 | 7-AZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | Eisai R&D Management Co., Ltd. (JP) | 2009-10-21 | — | — | EP | disclosed |
| WO-2008095944-A1 | 7-AZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | EISAI R&D MANAGEMENT CO. LTD. (JP) | 2008-08-14 | — | — | WO | disclosed |