Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 13/20 | 0.45 |
| ▸ | HRH1 | P35367 | 4/20 | 0.45 |
| ▸ | HTR2B | P41595 | 3/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 3/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.39 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3778597 | 0.94 | SSTR5 (0.49) | SSTR5HRH1HTR2BMCHR1ACHE | |
| SCHEMBL4224514 | 0.91 | SSTR5 (0.45) | SSTR5HRH1HTR2BMCHR1ACHE | |
| SCHEMBL4238432 | 0.88 | SSTR5 (0.46) | SSTR5HRH1HTR2BMCHR1ACHE | |
| SCHEMBL4235821 | 0.87 | SSTR5 (0.44) | SSTR5HRH1HTR2BACHEBACE1 | |
| SCHEMBL4234199 | 0.87 | SSTR5 (0.54) | SSTR5HRH1HTR2B | |
| SCHEMBL4235419 | 0.85 | SSTR5 (0.54) | SSTR5HRH1HTR2B | |
| SCHEMBL4238258 | 0.84 | SSTR5 (0.49) | SSTR5HRH1HTR2BACHE | |
| SCHEMBL3775060 | 0.84 | SSTR5 (0.49) | SSTR5HRH1HTR2BMCHR1ACHE | |
| SCHEMBL4224881 | 0.84 | SSTR5 (0.57) | SSTR5HRH1HTR2B | |
| SCHEMBL4238115 | 0.82 | SSTR5 (0.54) | SSTR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001867-B1 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-07-01 | — | — | EP | disclosed |
| CN-101405284-A | Pyrimidine, quinazoline, pteridine and derivatives | HOFFMANN LA ROCHE (CH) | 2009-04-08 | — | — | CN | disclosed |