Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 2/20 | 0.82 |
| ▸ | SYK | P43405 | 2/20 | 0.82 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.82 |
| ▸ | FES | P07332 | 1/20 | 0.82 |
| ▸ | FER | P16591 | 1/20 | 0.82 |
| ▸ | FRK | P42685 | 1/20 | 0.82 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.82 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.82 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.53 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL423587 | 1.00 | TYK2 (0.82) | TYK2SYKIRAK4FESFER | |
| SCHEMBL18115391 | 0.92 | TYK2 (0.85) | TYK2SYKIRAK4FESFER | |
| SCHEMBL18115397 | 0.92 | TYK2 (0.85) | TYK2SYKIRAK4FESFER | |
| SCHEMBL13758964 | 0.92 | TYK2 (0.69) | TYK2SYKIRAK4FESFER | |
| Apilimod SCHEMBL426299 | 0.90 | PIKFYVE (1.00) | TYK2SYKIRAK4FESFER | |
| SCHEMBL424541 | 0.90 | TYK2 (0.82) | TYK2SYKIRAK4FESFER | |
| SCHEMBL428783 | 0.90 | TYK2 (0.82) | TYK2SYKIRAK4FESFER | |
| SCHEMBL426792 | 0.90 | TYK2 (0.82) | TYK2SYKIRAK4FESFER | |
| SCHEMBL428784 | 0.90 | TYK2 (0.82) | TYK2SYKIRAK4FESFER | |
| Apilimod SCHEMBL426300 | 0.90 | PIKFYVE (1.00) | TYK2SYKIRAK4FESFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458687-B1 | PYRIMIDINE COMPOUNDS AS INTERLEUKIN-12 (IL-12) INHIBITORS | SYNTA PHARMACEUTICALS CORP (US) | 2012-01-11 | — | — | EP | claimed |
| US-20100120722-A1 | HETEROCYCLIC COMPOUNDS FOR PREVENTING AND TREATING DISORDERS ASSOCIATED WITH EXCESSIVE BONE LOSS | SYNTA PHARMACEUTICALS CORP. (US) | 2010-05-13 | — | — | US | claimed |
| US-20080058297-A1 | Heterocyclic Compounds For Preventing And Treating Disorders Associated With Excessive Bone Loss | SYNTA PHARMACEUTICALS CORP. (US) | 2008-03-06 | — | — | US | claimed |
| EP-1626725-A2 | HETEROCYCLIC COMPOUNDS FOR PREVENTING AND TREATING DISORDERS ASSOCIATED WITH EXCESSIVE BONE LOSS | Synta Pharmaceuticals Corporation (US) | 2006-02-22 | — | — | EP | claimed |
| EP-1458687-A4 | PYRIMIDINE COMPOUNDS | SYNTA PHARMACEUTICALS CORP (US) | 2005-03-23 | — | — | EP | claimed |
| WO-2005000404-A2 | HETEROCYCLIC COMPOUNDS FOR PREVENTING AND TREATING DISORDERS ASSOCIATED WITH EXCESSIVE BONE LOSS | SYNTA PHARMACEUTICALS, CORP. (US) | 2005-01-06 | — | — | WO | claimed |
| EP-1458687-A2 | PYRIMIDINE COMPOUNDS | Synta Pharmaceuticals Corporation (US) | 2004-09-22 | — | — | EP | claimed |
| WO-2003047516-A2 | PYRIMIDINE COMPOUNDS | SYNTA PHARMACEUTICALS CORPORATION (US) | 2003-06-12 | — | — | WO | claimed |
| US-20180092923-A1 | METHODS FOR TREATING LYSOSOMAL STORAGE DISORDERS | BIOMARIN PHARMACEUTICAL INC. | 2018-04-05 | — | — | US | disclosed |
| US-20180092923-A1 | METHODS FOR TREATING LYSOSOMAL STORAGE DISORDERS | BIOMARIN PHARMACEUTICAL INC. | 2018-04-05 | — | — | US | disclosed |
| WO-2016168420-A1 | METHODS FOR TREATING LYSOSOMAL STORAGE DISORDERS | BIOMARIN PHARMACEUTICAL INC. (US) | 2016-10-20 | — | — | WO | disclosed |
| US-20150174132-A1 | METHOD FOR TREATING B CELL REGULATED AUTOIMMUNE DISORDERS | SYNTA PHARMACEUTICALS CORP (US) | 2015-06-25 | — | — | US | disclosed |
| US-20150174132-A1 | METHOD FOR TREATING B CELL REGULATED AUTOIMMUNE DISORDERS | SYNTA PHARMACEUTICALS CORP (US) | 2015-06-25 | — | — | US | disclosed |
| US-20120021434-A1 | METHOD FOR TREATING B CELL REGULATED AUTOIMMUNE DISORDERS | SYNTA PHARMACEUTICALS CORP. (US) | 2012-01-26 | — | — | US | disclosed |
| US-20050250787-A1 | Pyrimidine compounds | MADRIGAL PHARMACEUTICALS, INC. | 2005-11-10 | — | — | US | disclosed |
| EP-1458687-A4 | PYRIMIDINE COMPOUNDS | SYNTA PHARMACEUTICALS CORP (US) | 2005-03-23 | — | — | EP | disclosed |
| US-6858606-B2 | Pyrimidine compounds | SYNTA PHARMACEUTICAL CORP. (US) | 2005-02-22 | — | — | US | disclosed |
| EP-1458687-A2 | PYRIMIDINE COMPOUNDS | Synta Pharmaceuticals Corporation (US) | 2004-09-22 | — | — | EP | disclosed |
| US-20040024206-A1 | Pyrimidine compounds | MADRIGAL PHARMACEUTICALS, INC. | 2004-02-05 | — | — | US | disclosed |
| WO-2003047516-A2 | PYRIMIDINE COMPOUNDS | SYNTA PHARMACEUTICALS CORPORATION (US) | 2003-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050250787-A1 | Pyrimidine compounds | RORC, MTR, CBR1 | TYK2 301/4885SYK 133/4885IRAK4 273/4885 |
| US-20150174132-A1 | METHOD FOR TREATING B CELL REGULATED AUTOIMMUNE DISORDERS | REL, NFATC1, BCL6 | TYK2 2464/4885SYK 737/4885IRAK4 660/4885 |
| US-20080058297-A1 | Heterocyclic Compounds For Preventing And Treating Disorders Associated With Excessive Bone Loss | BRCA1, VHL, ESR1 | TYK2 2409/4885SYK 3624/4885IRAK4 2390/4885 |
| US-20100120722-A1 | HETEROCYCLIC COMPOUNDS FOR PREVENTING AND TREATING DISORDERS ASSOCIATED WITH EXCESSIVE BONE LOSS | BRCA1, VHL, ESR1 | TYK2 2409/4885SYK 3624/4885IRAK4 2390/4885 |
| US-20180092923-A1 | METHODS FOR TREATING LYSOSOMAL STORAGE DISORDERS | GAA, GBA1, MAN2B1 | TYK2 4587/4885SYK 3861/4885IRAK4 4107/4885 |
| US-20040024206-A1 | Pyrimidine compounds | CBR1, CCR4, CNR1 | TYK2 702/4885SYK 814/4885IRAK4 121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.