Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28993736 | 0.76 | KCNH2 (0.41) | PTGS2KCNH2HPGDMEN1ALDH1A1 | |
| SCHEMBL6535135 | 0.74 | PTGS2 (0.60) | PTGS2NAAAEPHX2HPGDTSHR | |
| SCHEMBL7984395 | 0.71 | PTGS2 (0.63) | PTGS2NAAAEPHX2HPGDMAPT | |
| SCHEMBL2070118 | 0.70 | EPHX2 (0.62) | PTGS2NAAAEPHX2HPGDCYSLTR2 | |
| SCHEMBL29561042 | 0.70 | PTGS2 (0.36) | PTGS2KCNH2ALDH1A1MAPTCYSLTR2 | |
| SCHEMBL4280713 | 0.70 | KCNH2 (0.54) | NAAAKCNH2HPGDMEN1ALDH1A1 | |
| SCHEMBL31544587 | 0.70 | KCNH2 (0.54) | NAAAKCNH2HPGDMEN1ALDH1A1 | |
| SCHEMBL5313693 | 0.69 | EPHX2 (0.64) | PTGS2NAAAEPHX2MEN1ALDH1A1 | |
| SCHEMBL9447706 | 0.69 | EPHX2 (0.64) | PTGS2NAAAEPHX2MEN1ALDH1A1 | |
| SCHEMBL22444760 | 0.69 | EPHX2 (0.64) | PTGS2NAAAEPHX2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090252678-A1 | COX-2-TARGETED IMAGING AGENTS | VANDERBILT UNIVERSITY (US) | 2009-10-08 | — | — | US | disclosed |
| EP-1638612-A2 | COX-2-TARGETED IMAGING AGENTS | Vanderbilt University (US) | 2006-03-29 | — | — | EP | disclosed |
| US-20050002859-A1 | COX-2-targeted imaging agents | VANDERBILT UNIVERSITY (US) | 2005-01-06 | — | — | US | disclosed |
| WO-2005002293-A2 | COX-2-TARGETED IMAGING AGENTS | VANDERBILT UNIVERSITY (US) | 2005-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050002859-A1 | COX-2-targeted imaging agents | PTGS2, PTGES2, PTGER2 | PTGS2 1/4885NAAA 616/4885EPHX2 215/4885 |
| US-20090252678-A1 | COX-2-TARGETED IMAGING AGENTS | PTGS2, PTGES2, PTGER2 | PTGS2 1/4885NAAA 616/4885EPHX2 215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.