Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | NAAA | Q02083 | 1/20 | 0.31 |
| ▸ | IAPP | P10997 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18284602 | 0.76 | CCR1 (0.46) | TSHRGABRA1GABRB2LMNAIKBKB | |
| SCHEMBL22444451 | 0.75 | CCR1 (0.46) | TSHRGABRA1GABRB2LMNAIKBKB | |
| SCHEMBL22444566 | 0.75 | CCR1 (0.46) | TSHRGABRA1GABRB2LMNAIKBKB | |
| SCHEMBL22444762 | 0.75 | CCR1 (0.46) | TSHRGABRA1GABRB2LMNAIKBKB | |
| SCHEMBL6534963 | 0.75 | TSHR (0.50) | TSHRGABRA1GABRB2LMNAIKBKB | |
| SCHEMBL887607 | 0.74 | TSHR (0.53) | TSHRGABRA1GABRB2LMNAIKBKB | |
| SCHEMBL4981071 | 0.74 | TSHR (0.53) | TSHRGABRA1GABRB2LMNAALDH1A1 | |
| SCHEMBL8853304 | 0.74 | TSHR (0.53) | TSHRGABRA1GABRB2LMNAALDH1A1 | |
| SCHEMBL574034 | 0.73 | TSHR (0.68) | TSHRGABRA1GABRB2LMNAIKBKB | |
| SCHEMBL980886 | 0.71 | TSHR (0.55) | TSHRGABRA1GABRB2LMNAIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090252678-A1 | COX-2-TARGETED IMAGING AGENTS | VANDERBILT UNIVERSITY (US) | 2009-10-08 | — | — | US | disclosed |
| EP-1638612-A2 | COX-2-TARGETED IMAGING AGENTS | Vanderbilt University (US) | 2006-03-29 | — | — | EP | disclosed |
| US-20050002859-A1 | COX-2-targeted imaging agents | VANDERBILT UNIVERSITY (US) | 2005-01-06 | — | — | US | disclosed |
| WO-2005002293-A2 | COX-2-TARGETED IMAGING AGENTS | VANDERBILT UNIVERSITY (US) | 2005-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050002859-A1 | COX-2-targeted imaging agents | PTGS2, PTGES2, PTGER2 | TSHR 3905/4885GABRA1 2966/4885GABRB2 1523/4885 |
| US-20090252678-A1 | COX-2-TARGETED IMAGING AGENTS | PTGS2, PTGES2, PTGER2 | TSHR 3905/4885GABRA1 2966/4885GABRB2 1523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.