Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6690451 | 0.94 | TSHR (0.52) | TSHRGABRA1GABRB2ALDH1A1PPARG | |
| SCHEMBL30714953 | 0.94 | TSHR (0.52) | TSHRGABRA1GABRB2ALDH1A1PPARG | |
| SCHEMBL8517638 | 0.92 | TSHR (0.50) | TSHRGABRA1GABRB2ALDH1A1PPARG | |
| SCHEMBL22444751 | 0.92 | TSHR (0.50) | TSHRGABRA1GABRB2ALDH1A1PPARG | |
| SCHEMBL22444754 | 0.92 | TSHR (0.50) | TSHRGABRA1GABRB2ALDH1A1PPARG | |
| SCHEMBL4146572 | 0.92 | TSHR (0.50) | TSHRGABRA1GABRB2ALDH1A1PPARG | |
| SCHEMBL4738271 | 0.90 | TSHR (0.55) | TSHRGABRA1GABRB2LMNAALDH1A1 | |
| SCHEMBL8216569 | 0.87 | ALDH1A1 (0.46) | TSHRLMNAALDH1A1KDM4EPPARG | |
| SCHEMBL5792353 | 0.85 | TSHR (0.50) | TSHRGABRA1GABRB2LMNAALDH1A1 | |
| SCHEMBL9757096 | 0.85 | TSHR (0.55) | TSHRGABRA1GABRB2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858492-B1 | ORAL OSMOTIC DOSAGE FORM HAVING A HIGH FLUX MEMBRANE | ALZA CORP (US) | 2008-11-12 | — | — | EP | claimed |
| EP-0160258-B1 | (6,11-DIHYDRO-11-OXODIBENZ(BM,E)OXEPINYL)PENTANOLS, A PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-09-27 | — | — | EP | disclosed |
| EP-0160258-A2 | (6,11-Dihydro-11-oxodibenz(bm,e)oxepinyl)pentanols, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-11-06 | — | — | EP | disclosed |