Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GUSB | P08236 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27913426 | 0.80 | ALDH1A1 (0.45) | ALDH1A1HPGDKDM4EMAPTGUSB | |
| SCHEMBL8623920 | 0.80 | ALDH1A1 (0.45) | ALDH1A1HPGDKDM4EMAPTGUSB | |
| SCHEMBL1801990 | 0.80 | ALDH1A1 (0.45) | ALDH1A1HPGDKDM4EMAPTCYP1A2 | |
| SCHEMBL15389969 | 0.77 | ALDH1A1 (0.51) | ALDH1A1HPGDKDM4ECYP1A2LMNA | |
| SCHEMBL7111827 | 0.73 | KMT2A (0.50) | ALDH1A1HPGDKDM4EMAPTGUSB | |
| SCHEMBL6583480 | 0.72 | ALDH1A1 (0.48) | ALDH1A1HPGDKDM4EMAPTGUSB | |
| SCHEMBL28304704 | 0.72 | ALDH1A1 (0.48) | ALDH1A1HPGDKDM4EMAPTGUSB | |
| SCHEMBL12722762 | 0.72 | ALDH1A1 (0.48) | ALDH1A1HPGDKDM4EMAPTGUSB | |
| SCHEMBL19034219 | 0.71 | ALDH1A1 (0.50) | ALDH1A1HPGDKDM4EMAPTCYP1A2 | |
| SCHEMBL500318 | 0.71 | ALDH1A1 (0.46) | ALDH1A1HPGDKDM4EMAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014106122-A1 | COMPOSITIONS AND METHODS FOR BIO-BUTADIENE PRODUCTION SCREENING | GENOMATICA, INC. (US) | 2014-07-03 | — | — | WO | claimed |
| US-20150238466-A1 | LIM KINASE INHIBITORS | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2015-08-27 | — | — | US | disclosed |
| EP-2867201-A1 | LIM KINASE INHIBITORS | Ramot at Tel-Aviv University Ltd. (IL) | 2015-05-06 | — | — | EP | disclosed |
| WO-2014106122-A1 | COMPOSITIONS AND METHODS FOR BIO-BUTADIENE PRODUCTION SCREENING | GENOMATICA, INC. (US) | 2014-07-03 | — | — | WO | disclosed |
| WO-2014002101-A1 | LIM KINASE INHIBITORS | RAMOT AT TEL-AVIV UNIVERSITY LTD (IL) | 2014-01-03 | — | — | WO | disclosed |
| WO-2009124226-A2 | GELSOLIN USES IN NEUROLOGICAL DISORDERS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2009-10-08 | — | — | WO | disclosed |
| US-7282571-B2 | Methods for stabilizing proteins | CYTOSKELETON INC. (US) | 2007-10-16 | — | — | US | disclosed |
| US-20050171341-A1 | Concentrating a pyrene actin; mixing the concentrated pyrene actin with sucrose, a stabilizing agent, and a reducing agent, rapidly freezing | DAVIS ASHLEY S (US) | 2005-08-04 | — | — | US | disclosed |
| US-20050084853-A1 | Aspergillus fumigatus profilin | NISLOW COREY (US) | 2005-04-21 | — | — | US | disclosed |
| US-6780987-B1 | NUCLEIC ACIDS MOLECULES, DESIGNATED BETA CAP73 NUCLEIC ACID MOLECULES, WHICH ENCODE A NOVEL ACTIN BINDING PROTEIN; DIAGNOSTIC AND THERAPEUTIC METHODS UTILIZING COMPOSITIONS OF THE PROTEINS | TRUSTEES OF THE TUFTS COLLEGE | 2004-08-24 | — | — | US | disclosed |
| US-6403372-B1 | Aspergillus fumigatus profilin | CYTOKINETICS, INC. | 2002-06-11 | — | — | US | disclosed |
| WO-2002042467-A2 | ASPERGILLUS FUMIGATUS PROFILIN | CYTOKINETICS (US) | 2002-05-30 | — | — | WO | disclosed |
| WO-2002042451-A2 | ASPERGILLUS FUMIGATUS COFILIN | CYTOKINETICS (US) | 2002-05-30 | — | — | WO | disclosed |
| EP-0655089-B1 | EFFECTS OF ACTIN FILAMENTS ON FIBRIN CLOT STRUCTURE AND LYSIS | BRIGHAM & WOMENS HOSPITAL (US) | 2000-11-08 | — | — | EP | disclosed |
| US-5691160-A | Effects of actin filaments of fibrin clot structure and lysis | BIOGEN, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| EP-0655089-A4 | EFFECTS OF ACTIN FILAMENTS ON FIBRIN CLOT STRUCTURE AND LYSIS. | BRIGHAM & WOMENS HOSPITAL (US) | 1997-04-02 | — | — | EP | disclosed |
| EP-0655089-A1 | EFFECTS OF ACTIN FILAMENTS ON FIBRIN CLOT STRUCTURE AND LYSIS | BRIGHAM AND WOMEN'S HOSPITAL (US) | 1995-05-31 | — | — | EP | disclosed |
| WO-1994004704-A1 | EFFECTS OF ACTIN FILAMENTS ON FIBRIN CLOT STRUCTURE AND LYSIS | BRIGHAM AND WOMEN'S HOSPITAL (US) | 1994-03-03 | — | — | WO | disclosed |
| WO-1993025564-A1 | PHOSPHOINOSITIDE-BINDING PEPTIDES DERIVED FROM THE SEQUENCES OF GELSOLIN AND VILLIN | BRIGHAM AND WOMEN'S HOSPITAL (US) | 1993-12-23 | — | — | WO | disclosed |
| US-4537718-A | GLUTATHIONE JOINED BY LINKAGE GROUPS TO A SECTROSCOPIC REPORTER | COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 1985-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150238466-A1 | LIM KINASE INHIBITORS | LIMK1, LIMK2, LIMA1 | ALDH1A1 4701/4885HPGD 3640/4885KDM4E 1739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.