Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 7/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | TACR3 | P29371 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.32 |
| ▸ | FEN1 | P39748 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4237147 | 0.77 | MAPK11 (0.52) | MAPK11MAPK13MAPK14MAPK12CYP2C9 | |
| SCHEMBL4239955 | 0.77 | MAPK11 (0.51) | MAPK11MAPK13MAPK14MAPK12CYP2C9 | |
| SCHEMBL5806925 | 0.77 | MAPK11 (0.51) | MAPK11MAPK13MAPK14MAPK12CYP2C9 | |
| SCHEMBL4245676 | 0.76 | MAPK11 (0.48) | MAPK11MAPK13MAPK14MAPK12CYP2C9 | |
| SCHEMBL4241190 | 0.76 | MAPK11 (0.49) | MAPK11MAPK13MAPK14MAPK12CYP2C9 | |
| SCHEMBL4243488 | 0.75 | MAPK11 (0.50) | MAPK11MAPK13MAPK14MAPK12CYP2C9 | |
| SCHEMBL4240260 | 0.75 | MAPK11 (0.53) | MAPK11MAPK13MAPK14MAPK12CYP2C9 | |
| SCHEMBL4243757 | 0.75 | MAPK11 (0.51) | MAPK11MAPK13MAPK14MAPK12CYP2C9 | |
| SCHEMBL4245632 | 0.75 | MAPK11 (0.51) | MAPK11MAPK13MAPK14MAPK12CYP2C9 | |
| SCHEMBL4240304 | 0.75 | MAPK11 (0.48) | MAPK11MAPK13MAPK14MAPK12CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042856-A1 | PYRIDAZINONE DERIVATIVES USED FOR THE TREATMENT OF PAIN | ASTELLAS PHARMA INC (JP) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042856-A1 | PYRIDAZINONE DERIVATIVES USED FOR THE TREATMENT OF PAIN | HRH2, OPRD1, HRH4 | MAPK11 1195/4885MAPK13 1439/4885MAPK14 852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.