Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 6/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 6/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 6/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 10/20 | 0.44 |
| ▸ | ITGAV | P06756 | 10/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 10/20 | 0.44 |
| ▸ | PTGIR | P43119 | 3/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 7/20 | 0.41 |
| ▸ | ITGB5 | P18084 | 7/20 | 0.41 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2836514 | 1.00 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CITGB3ITGAV | |
| SCHEMBL2837003 | 0.95 | ITGB3 (0.48) | ADRA2AADRA2BADRA2CITGB3ITGAV | |
| SCHEMBL2836387 | 0.93 | ITGB3 (0.43) | ADRA2AADRA2BADRA2CITGB3ITGAV | |
| SCHEMBL2834304 | 0.91 | ITGB3 (0.55) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL4562249 | 0.91 | ITGB3 (0.55) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL2842106 | 0.91 | ITGB3 (0.46) | ADRA2AADRA2BADRA2CITGB3ITGAV | |
| SCHEMBL2833052 | 0.88 | ITGB3 (0.44) | ADRA2AADRA2BADRA2CITGB3ITGAV | |
| SCHEMBL4372793 | 0.87 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CITGB3ITGAV | |
| SCHEMBL2833713 | 0.87 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CITGB3ITGAV | |
| SCHEMBL2833818 | 0.86 | ITGB3 (0.60) | ITGB3ITGAVITGA2BITGB1ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009061448-A9 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PROTEINURIC DISEASES | THE GENERAL HOSPITAL CORPORATION (US) | 2009-08-13 | — | — | WO | disclosed |