SCHEMBL4237337

SCHEMBL4237337

Cc1ccc(N(c2ccc(C)cc2)c2ccc(C=Cc3ccc(C=CC(=O)O)cc3)cc2)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPM8 Q7Z2W7 3/20 0.55
FOS P01100 1/20 0.53
JUN P05412 1/20 0.53
HCAR2 Q8TDS4 2/20 0.52
CA12 O43570 1/20 0.52
AKR1B10 O60218 1/20 0.52
CA1 P00915 1/20 0.52
CA2 P00918 1/20 0.52
ESR1 P03372 1/20 0.52
CA3 P07451 1/20 0.52
PKM P14618 1/20 0.52
TYR P14679 1/20 0.52
AKR1B1 P15121 1/20 0.52
CA4 P22748 1/20 0.52
CA6 P23280 1/20 0.52
DPP4 P27487 1/20 0.52
CA5A P35218 1/20 0.52
CA7 P43166 1/20 0.52
CA9 Q16790 1/20 0.52
ESR2 Q92731 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16353266 1.00 TRPM8 (0.55) TRPM8FOSJUNHCAR2CA12
SCHEMBL16353263 1.00 TRPM8 (0.55) TRPM8FOSJUNHCAR2CA12
SCHEMBL16353253 0.98 TRPM8 (0.57) TRPM8FOSJUNHCAR2CA12
SCHEMBL16353227 0.98 TRPM8 (0.57) TRPM8FOSJUNHCAR2CA12
SCHEMBL16353247 0.95 TRPM8 (0.63) TRPM8FOSJUNHCAR2CA12
SCHEMBL17321087 0.93 TRPM8 (0.53) TRPM8FOSJUNHCAR2CA12
SCHEMBL4237469 0.91 TRPM8 (0.51) TRPM8FOSJUNHCAR2MAPT
SCHEMBL17324184 0.89 KDM4E (0.55) TRPM8FOSJUNHCAR2CA12
SCHEMBL17321127 0.89 TRPM8 (0.60) TRPM8FOSJUNHCAR2CA12
SCHEMBL338547 0.88 TRPM8 (0.51) TRPM8FOSJUNHCAR2CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7507509-B2 Electrophotographic photoreceptor, and image forming method, image forming apparatus and process cartridge using the electrophotographic photoreceptor RICOH COMPANY, LTD. (JP) 2009-03-24 US disclosed
US-20060078809-A1 Electrophotographic photoreceptor, and image forming method, image forming apparatus and process cartridge using the electrophotographic photoreceptor RICOH COMPANY, LTD. (JP) 2006-04-13 US disclosed