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SCHEMBL4237402

SCHEMBL4237402

CCOC(=O)CC(C(=O)c1ccc(OC2CCN(C(=O)OC(C)(C)C)CC2)cc1)S(C)(=O)=O

nearest known ligand 0.58

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 13/20 0.58
▸ PDE4D Q08499 3/20 0.45
▸ PDE4A P27815 2/20 0.45
▸ PDE4B Q07343 2/20 0.45
▸ PDE4C Q08493 2/20 0.45
▸ CHEK2 O96017 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1376593 0.88 GPR119 (0.53) GPR119PDE4DPDE4APDE4BPDE4C
SCHEMBL1375168 0.81 GPR119 (0.61) GPR119PDE4DPDE4APDE4BPDE4C
SCHEMBL1376438 0.81 PDE4D (0.56) GPR119PDE4DPDE4APDE4BPDE4C
SCHEMBL3618563 0.80 GPR119 (0.46) GPR119PDE4DPDE4APDE4BPDE4C
SCHEMBL12017713 0.80 GPR119 (0.53) GPR119PDE4DPDE4APDE4BPDE4C
SCHEMBL7380480 0.79 GPR119 (0.59) GPR119PDE4DPDE4APDE4BPDE4C
SCHEMBL6192490 0.79 GPR119 (0.62) GPR119PDE4DPDE4APDE4BPDE4C
SCHEMBL1373307 0.79 GPR119 (0.54) GPR119PDE4DPDE4APDE4BPDE4C
SCHEMBL1375233 0.77 GPR119 (0.54) GPR119PDE4DPDE4APDE4BPDE4C
SCHEMBL5864771 0.77 GPR119 (0.57) GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2069312-A2 PYRIDIZINONE DERIVATIVES Cephalon, Inc. (US) 2009-06-17 — — EP disclosed
WO-2008013838-A2 PYRIDIZINONE DERIVATIVES CEPHALON, INC. (US) 2008-01-31 — — WO disclosed