Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18475075 | 0.86 | SLC6A2 (0.51) | SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL18428966 | 0.84 | SLC6A2 (0.50) | SLC6A2SLC6A4 | |
| SCHEMBL18469960 | 0.84 | NOS3 (0.35) | SLC6A2SLC6A4 | |
| SCHEMBL22989499 | 0.80 | SLC6A2 (0.33) | SLC6A2SLC6A4 | |
| SCHEMBL9284811 | 0.78 | SLC6A2 (0.35) | SLC6A2SLC6A4 | |
| SCHEMBL18440487 | 0.77 | ACKR3 (0.38) | SLC6A2SLC6A4 | |
| SCHEMBL835196 | 0.76 | — | — | |
| SCHEMBL9862148 | 0.76 | ADH1C (0.33) | SLC6A2SLC6A4 | |
| SCHEMBL9278394 | 0.71 | ADH1C (0.34) | SLC6A2SLC6A4 | |
| SCHEMBL24120114 | 0.71 | SLC6A2 (0.39) | SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140315931-A1 | DEAZAPURINES USEFUL AS INHIBITORS OF JANUS KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-10-23 | — | — | US | disclosed |
| US-8741912-B2 | Deazapurines useful as inhibitors of Janus kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-06-03 | — | — | US | disclosed |
| US-20120316186-A1 | DEAZAPURINES USEFUL AS INHIBITORS OF JANUS KINASES | VERTEX PHARMACEUTICALS INCORPORATED | 2012-12-13 | — | — | US | disclosed |
| US-20090088445-A1 | Deazapurines useful as inhibitors of Janus kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2009-04-02 | — | — | US | disclosed |
| EP-2001884-A1 | DEAZAPURINES USEFUL AS INHIBITORS OF JANUS KINASES | Vertex Pharmaceuticals, Inc. (US) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007117494-A1 | DEAZAPURINES USEFUL AS INHIBITORS OF JANUS KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-18 | — | — | WO | disclosed |
| CN-1499972-A | Imidazolyl derivatives as corticotropin releasing factor inhibitors | ����˹�ж�-����˹˹������˾ | 2004-05-26 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088445-A1 | Deazapurines useful as inhibitors of Janus kinases | JAK1, JAK3, JAK2 | SLC6A2 4449/4885SLC6A4 4548/4885 |
| US-20140315931-A1 | DEAZAPURINES USEFUL AS INHIBITORS OF JANUS KINASES | JAK1, JAK3, JAK2 | SLC6A2 4449/4885SLC6A4 4548/4885 |
| US-20120316186-A1 | DEAZAPURINES USEFUL AS INHIBITORS OF JANUS KINASES | JAK1, JAK3, JAK2 | SLC6A2 4449/4885SLC6A4 4548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.