Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4232597 | 0.90 | PIK3CD (0.42) | PIK3CDNPC1RAB9APDE4APDE4B | |
| SCHEMBL4232120 | 0.87 | PIK3CD (0.38) | PIK3CDPOLBRAB9APDE4APDE4B | |
| SCHEMBL4234577 | 0.86 | PIK3CD (0.50) | PIK3CDRXFP1RAB9APDE4APDE4B | |
| SCHEMBL4236551 | 0.81 | PIK3CD (0.43) | PIK3CDPOLBRXFP1RAB9APDE4A | |
| SCHEMBL1703384 | 0.78 | PIK3CD (0.51) | PIK3CDPDE4DPDE3A | |
| SCHEMBL5608379 | 0.78 | ALDH1A1 (0.48) | PIK3CDRXFP1NPC1RAB9AALDH1A1 | |
| SCHEMBL5607341 | 0.77 | PIK3CD (0.50) | PIK3CDPDE4DPDE3A | |
| SCHEMBL4237068 | 0.76 | POLB (0.54) | PIK3CDPOLBRXFP1NPC1RAB9A | |
| SCHEMBL4229400 | 0.76 | POLB (0.51) | POLBRXFP1NPC1RAB9APDE4A | |
| SCHEMBL5607724 | 0.75 | PIK3CD (0.51) | PIK3CDPDE4DPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097422-A1 | THIENOPYRIMIDINONES FOR TREATMENT OF INFLAMMATORY DISORDERS AND CANCERS | Eli Lilly & Co. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008064018-A1 | THIENOPYRIMIDINONES FOR TREATMENT OF INFLAMMATORY DISORDERS AND CANCERS | ELI LILLY & CO. (US) | 2008-05-29 | — | — | WO | disclosed |