Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 5/20 | 0.70 |
| ▸ | ABL1 | P00519 | 4/20 | 0.68 |
| ▸ | BCR | P11274 | 4/20 | 0.68 |
| ▸ | EGFR | P00533 | 1/20 | 0.61 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | SYK | P43405 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | KIF11 | P52732 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4239378 | 0.86 | ABL1 (0.69) | AURKAABL1BCRKDM4EMAPT | |
| SCHEMBL1387447 | 0.85 | THRB (0.80) | AURKAABL1BCREGFRERBB4 | |
| SCHEMBL4235267 | 0.84 | AURKA (0.55) | AURKAABL1BCREGFRERBB4 | |
| SCHEMBL4234986 | 0.84 | AURKA (0.55) | AURKAABL1BCREGFRERBB4 | |
| SCHEMBL3694508 | 0.82 | AURKA (1.00) | AURKASYK | |
| SCHEMBL4237476 | 0.82 | AURKA (1.00) | AURKASYK | |
| SCHEMBL242231 | 0.81 | EGFR (0.52) | AURKAABL1BCREGFRERBB4 | |
| SCHEMBL4239042 | 0.80 | THRB (0.68) | AURKAEGFRERBB4THRBKDM4E | |
| SCHEMBL4237718 | 0.80 | THRB (0.55) | AURKAABL1BCREGFRERBB4 | |
| SCHEMBL6430910 | 0.79 | MAPT (0.70) | AURKAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181991-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC | 2009-07-16 | — | — | US | claimed |
| EP-1943233-A2 | COMPOUNDS AND COMPOSITIONS FOR PROTEIN KINASE INHBITORS | IRM, LLC (BM) | 2008-07-16 | — | — | EP | claimed |
| WO-2007056151-A2 | PROTEIN KINASE INHBITORS | IRM LLC (BM) | 2007-05-18 | — | — | WO | claimed |
| US-12018280-B2 | Method for freezing aggregates of pluripotent stem cell-derived cardiomyocytes | KYOTO UNIVERSITY (JP) | 2024-06-25 | — | — | US | disclosed |
| EP-3431584-B1 | METHODS FOR FREEZING AN AGGREGATE OF PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES | UNIV KYOTO (JP) | 2023-06-28 | — | — | EP | disclosed |
| WO-2023286772-A1 | CARDIOMYOCYTE PRODUCTION METHOD | 三菱ケミカル株式会社 | 2023-01-19 | — | — | WO | disclosed |
| US-20200325448-A1 | METHOD FOR FREEZING AGGREGATES OF PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES | KYOTO UNIVERSITY (JP) | 2020-10-15 | — | — | US | disclosed |
| EP-3150705-B1 | METHOD FOR INDUCING MYOCARDIAL DIFFERENTIATION OF PLURIPOTENT STEM CELLS USING LOW-MOLECULAR COMPOUND | UNIV KYOTO (JP) | 2019-05-15 | — | — | EP | disclosed |
| EP-2966166-B1 | PROMOTER OF DIFFERENTIATION OF PLURIPOTENT STEM CELL INTO MYOCARDIUM, WHICH COMPRISES EGF RECEPTOR INHIBITOR | UNIV KYOTO (JP) | 2019-04-03 | — | — | EP | disclosed |
| US-10233426-B2 | Method for inducing cardiac differentiation of pluripotent stem cell with low-molecular compounds | KYOTO UNIVERSITY (JP) | 2019-03-19 | — | — | US | disclosed |
| US-10196609-B2 | Composition for promoting cardiac differentiation of pluripotent stem cell comprising EGFR inhibitor | KYOTO UNIVERSITY (JP) | 2019-02-05 | — | — | US | disclosed |
| EP-3431584-A1 | FREEZING METHOD FOR AGGREGATES OF PLURIPOTENT STEM CELL-DERIVED MYOCARDIAL CELLS | Kyoto University (JP) | 2019-01-23 | — | — | EP | disclosed |
| US-20170152485-A1 | Method for Inducing Cardiac Differentiation of Pluripotent Stem Cell with Low-Molecular Compounds | KYOTO UNIVERSITY (JP) | 2017-06-01 | — | — | US | disclosed |
| EP-3150705-A1 | METHOD FOR INDUCING MYOCARDIAL DIFFERENTIATION OF PLURIPOTENT STEM CELLS USING LOW-MOLECULAR COMPOUND | Kyoto University (JP) | 2017-04-05 | — | — | EP | disclosed |
| EP-2966166-A1 | PROMOTER OF DIFFERENTIATION OF PLURIPOTENT STEM CELL INTO MYOCARDIUM, WHICH COMPRISES EGF RECEPTOR INHIBITOR | Kyoto University (JP) | 2016-01-13 | — | — | EP | disclosed |
| US-20160002600-A1 | COMPOSITION FOR PROMOTING CARDIAC DIFFERENTIATION OF PLURIPOTENT STEM CELL COMPRISING EGFR INHIBITOR | KYOTO UNIVERSITY (JP) | 2016-01-07 | — | — | US | disclosed |
| CN-103242241-A | Salt of cyclopropane-carboxylic acid amide derivative | SHANGHAI YIZHI MEDICAL TECH CO | 2013-08-14 | — | — | CN | disclosed |
| US-20090181991-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC | 2009-07-16 | — | — | US | disclosed |
| EP-1943233-A2 | COMPOUNDS AND COMPOSITIONS FOR PROTEIN KINASE INHBITORS | IRM, LLC (BM) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007056151-A2 | PROTEIN KINASE INHBITORS | IRM LLC (BM) | 2007-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10233426-B2 | Method for inducing cardiac differentiation of pluripotent stem cell with low-molecular compounds | SRC, MYLK2, YES1 | AURKA 776/4885ABL1 108/4885BCR 799/4885 |
| US-20090181991-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | ERBB2, BMX, ERBB3 | AURKA 43/4885ABL1 75/4885BCR 313/4885 |
| US-20200325448-A1 | METHOD FOR FREEZING AGGREGATES OF PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES | TNNI3, MYLK2, TNNT2 | AURKA 916/4885ABL1 3347/4885BCR 3594/4885 |
| US-12018280-B2 | Method for freezing aggregates of pluripotent stem cell-derived cardiomyocytes | TNNI3, MYLK2, TNNT2 | AURKA 916/4885ABL1 3347/4885BCR 3594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.