Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CARM1 | Q86X55 | 12/20 | 0.51 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.47 |
| ▸ | KLK1 | P06870 | 1/20 | 0.47 |
| ▸ | GLS | O94925 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4239185 | 1.00 | LMNA (0.58) | LMNACARM1PI4KBKDM4EMAPK1 | |
| SCHEMBL15602694 | 0.79 | CARM1 (0.57) | CARM1 | |
| SCHEMBL14438334 | 0.78 | LMNA (0.53) | LMNAPI4KBKDM4EMAPK1GLS | |
| SCHEMBL21583900 | 0.78 | LMNA (0.56) | LMNAGLS | |
| SCHEMBL4404243 | 0.78 | LMNA (0.54) | LMNAPI4KBKDM4EMAPK1KLKB1 | |
| SCHEMBL17864341 | 0.76 | LMNA (0.60) | LMNAPI4KBKDM4EMAPK1KLKB1 | |
| SCHEMBL13452467 | 0.76 | LMNA (0.57) | LMNAPI4KBKDM4EMAPK1KLKB1 | |
| SCHEMBL12643749 | 0.75 | PPID (0.59) | LMNAPI4KBKDM4EMAPK1KLKB1 | |
| SCHEMBL8132918 | 0.75 | LMNA (0.48) | LMNAPI4KBKDM4EMAPK1KLKB1 | |
| SCHEMBL14987434 | 0.74 | LMNA (0.65) | LMNAPI4KBGLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009010871-A2 | PYRAZOLE DERIVATIVES AS ANTAGONISTS OF ADENOSINE A3 RECEPTOR | ADDEX PHARMA S.A. (CH) | 2009-01-22 | — | — | WO | disclosed |