Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | GLS | O94925 | 2/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.45 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.45 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | KLK1 | P06870 | 1/20 | 0.42 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13452467 | 0.84 | LMNA (0.57) | LMNAGLSPI4KBMPOERCC1 | |
| SCHEMBL28079351 | 0.82 | LMNA (0.61) | LMNAGLSPI4KBMPOERCC1 | |
| SCHEMBL17864343 | 0.82 | NOTUM (0.53) | LMNAMPOKDM4EMAPK1NOTUM | |
| SCHEMBL14438334 | 0.81 | LMNA (0.53) | LMNAGLSPI4KBMPOKDM4E | |
| SCHEMBL15432474 | 0.81 | LMNA (0.53) | LMNAGLSPI4KBMPOKDM4E | |
| SCHEMBL25426507 | 0.79 | DGAT2 (0.53) | LMNAKDM4EMEN1MAPTKMT2A | |
| SCHEMBL30245937 | 0.79 | DGAT2 (0.53) | LMNAKDM4EMEN1MAPTKMT2A | |
| SCHEMBL17629558 | 0.79 | LMNA (0.57) | LMNAGLSMPOERCC1ERCC4 | |
| SCHEMBL1793682 | 0.79 | LMNA (0.78) | LMNAGLSMPOERCC1ERCC4 | |
| SCHEMBL327273 | 0.79 | LMNA (0.57) | LMNAGLSMPOERCC1ERCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016095089-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |