SCHEMBL423925

SCHEMBL423925

NCC1OCCCO1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL94099 0.87
SCHEMBL8612074 0.84
SCHEMBL4394008 0.77
Alcohol SCHEMBL11301331 0.77 ALDH1A1 (0.33)
SCHEMBL3457354 0.73 TSHR (0.33)
SCHEMBL18282347 0.73 TSHR (0.33)
SCHEMBL13884643 0.73
SCHEMBL4396289 0.73 SIGMAR1 (0.33)
SCHEMBL716409 0.71
SCHEMBL1840595 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3456721-B1 METHOD OF PRODUCING COMPOUNDS HAVING HIV INTEGRASE INHIVITORY ACTIVITY SHIONOGI & CO (JP) 2021-02-24 EP disclosed
EP-3456721-A2 METHOD OF PRODUCING COMPOUNDS HAVING HIV INTEGRASE INHIVITORY ACTIVITY Shionogi & Co., Ltd (JP) 2019-03-20 EP disclosed
EP-3127908-B1 PROCESS FOR PREPARING COMPOUND HAVING HIV INTEGRASE INHIBITORY ACTIVITY SHIONOGI & CO (JP) 2018-11-28 EP disclosed
US-10125147-B2 Crystalline methyl (4R,12aS)-7-(benzyloxy)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylate SHIONOGI & CO., LTD. (JP) 2018-11-13 US disclosed
US-10125146-B2 Crystalline methyl (4R,12aS)-7-(benzyloxy)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylate SHIONOGI & CO., LTD. (JP) 2018-11-13 US disclosed
US-10000508-B2 Crystalline dimethyl 3-(benzyloxy)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate SHIONOGI & CO., LTD (JP) 2018-06-19 US disclosed
US-9969750-B2 Method of producing (3S,11aR)-6,8-dihalo-3-methyl-2,3,11,11a-tetrahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-5,7-diones SHIONOGI AND CO., LTD. (JP) 2018-05-15 US disclosed
US-20180044351-A1 METHODS OF PRODUCING COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY SHIONOGI & CO., LTD. (JP) 2018-02-15 US disclosed
US-20180037593-A1 METHODS OF PRODUCING COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY SHIONOGI & CO., LTD. (JP) 2018-02-08 US disclosed
US-20180037591-A1 METHODS OF PRODUCING COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY SHIONOGI & CO., LTD. (JP) 2018-02-08 US disclosed
EP-1537096-B1 DERIVATIVES OF DIOXANE-2-ALKYL CARBAMATES, PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS SANOFI AVENTIS (FR) 2008-09-24 EP disclosed
US-20070054084-A1 Optical recording medium and compound used for the same MITSUI CHEMICALS, INC. (JP) 2007-03-08 US disclosed
CN-1867980-A Optical recording medium and compound for use in the same MITSUI CHEMICALS INC (JP) 2006-11-22 CN disclosed
EP-1672626-A1 OPTICAL RECORDING MEDIUM AND COMPOUND USED IN THE OPTICAL RECORDING MEDIUM Mitsui Chemicals, Inc. (JP) 2006-06-21 EP disclosed
EP-0253235-B1 1,8-BRIDGED 4-QUINOLONE CARBOXYLIC ACIDS AND MEDICAMENTS CONTANING THEM BAYER AG (DE) 1991-01-02 EP disclosed
US-4816451-A Antibacterial 1,8-bridged 4-quinolonecarboxylic acids BAYER AKTIENGESELLSCHAFT (DE) 1989-03-28 US disclosed
EP-0253235-A1 1,8-Bridged 4-quinolone carboxylic acids and medicaments contaning them BAYER AG (DE) 1988-01-20 EP disclosed
US-4478634-A HERBICIDES VELSICOL CHEMICAL CORPORATION (US) 1984-10-23 US disclosed
US-4402729-A HERBICIDES VELSICOL CHEMICAL CORPORATION (US) 1983-09-06 US disclosed
US-3951640-A HERBICIDES VELSICOL CHEMICAL CORPORATION (US) 1976-04-20 US disclosed