SCHEMBL4239275

SCHEMBL4239275

N#CCc1cccc2c1ccn2C(=O)OCc1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TACR3 P29371 1/20 0.41
CTRB1 P17538 1/20 0.38
P2RX4 Q99571 2/20 0.38
KDM1A O60341 1/20 0.37
MAOA P21397 1/20 0.37
RCOR1 Q9UKL0 1/20 0.37
KMT2A Q03164 2/20 0.37
MEN1 O00255 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
P2RX1 P51575 1/20 0.37
P2RX3 P56373 1/20 0.37
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
ALDH1A1 P00352 3/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
HTR2C P28335 1/20 0.36
MAPK1 P28482 1/20 0.35
SLC6A2 P23975 1/20 0.35
SLC6A3 Q01959 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7166755 0.85 TACR3 (0.51) TACR3CTRB1P2RX4KDM1AMAOA
SCHEMBL4231904 0.85 TACR3 (0.46) TACR3CTRB1P2RX4KDM1AMAOA
SCHEMBL4232805 0.84 TACR3 (0.43) TACR3CTRB1P2RX4KDM1AMAOA
SCHEMBL3375069 0.80 TDP1 (0.47) TACR3CTRB1P2RX4KDM1AMAOA
SCHEMBL13309267 0.79 NPC1 (0.48) TACR3CTRB1P2RX4KDM1AMAOA
SCHEMBL4235703 0.77 P2RX4 (0.40) TACR3CTRB1P2RX4KDM1AMAOA
SCHEMBL29015481 0.77 HTR6 (0.46) KDM1AMAOARCOR1KMT2AMEN1
SCHEMBL30772188 0.76 KMT2A (0.41) TACR3CTRB1P2RX4KDM1AMAOA
SCHEMBL7162130 0.74 L3MBTL1 (0.53) CTRB1P2RX4KMT2AMEN1NPSR1
SCHEMBL16399234 0.73 TACR3 (0.53) TACR3CTRB1P2RX4KDM1AMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009115874-A2 NOVEL HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION MATRIX LABORATORIES LTD. (IN) 2009-09-24 WO disclosed