Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.48 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.43 |
| ▸ | NADK | O95544 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.35 |
| ▸ | ADK | P55263 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4239465 | 1.00 | ADORA2A (0.48) | ADORA2AADORA2BHSPA8NADKADORA3 | |
| SCHEMBL3880247 | 1.00 | ADORA2A (0.48) | ADORA2AADORA2BHSPA8NADKADORA3 | |
| SCHEMBL4031221 | 0.89 | ADORA2A (0.50) | ADORA2AADORA2BHSPA8ADORA3HSPA5 | |
| SCHEMBL13855562 | 0.88 | ADORA2A (0.49) | ADORA2AADORA2BHSPA8ADORA3HSPA5 | |
| SCHEMBL13855522 | 0.87 | HSPA8 (0.60) | ADORA2AADORA2BHSPA8ADORA3HSPA5 | |
| SCHEMBL13855561 | 0.82 | HSPA8 (0.48) | ADORA2AADORA2BHSPA8ADORA3HSPA5 | |
| SCHEMBL3879857 | 0.79 | ADORA2A (0.75) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL13855523 | 0.78 | SLC28A2 (0.51) | ADORA2AADORA2BHSPA8HSPA5FBP1 | |
| SCHEMBL3877828 | 0.77 | SLC28A2 (0.55) | ADORA2AADORA2BHSPA8HSPA5FBP1 | |
| SCHEMBL13855521 | 0.77 | SLC28A2 (0.55) | ADORA2AADORA2BHSPA8HSPA5FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118220-A1 | SUBSTITUTED ADENINES AND THE USES THEREOF | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118220-A1 | SUBSTITUTED ADENINES AND THE USES THEREOF | HPRT1, APRT, NUDT1 | ADORA2A 37/4885ADORA2B 51/4885HSPA8 4053/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.