Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 6/20 | 0.36 |
| ▸ | RAB9A | P51151 | 6/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.34 |
| ▸ | RELA | Q04206 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4061311 | 0.82 | MEN1 (0.57) | TRPV4SMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL4236400 | 0.76 | ACHE (0.42) | TRPV4SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL4237345 | 0.74 | KDR (0.40) | TRPV4SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL4241119 | 0.73 | ACHE (0.41) | TRPV4ACHE | |
| SCHEMBL3357298 | 0.68 | MEN1 (0.43) | SMN1; SMN2MEN1KMT2AMAPTLMNA | |
| SCHEMBL4058319 | 0.65 | NPC1 (0.55) | TRPV4SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL4237850 | 0.61 | NPC1 (0.56) | TRPV4SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL4235797 | 0.58 | KDR (0.40) | SMN1; SMN2MEN1KMT2AMAPTLMNA | |
| SCHEMBL31661254 | 0.57 | MEN1 (0.72) | TRPV4SMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL525388 | 0.57 | EGFR (0.58) | TRPV4SMN1; SMN2MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009010871-A2 | PYRAZOLE DERIVATIVES AS ANTAGONISTS OF ADENOSINE A3 RECEPTOR | ADDEX PHARMA S.A. (CH) | 2009-01-22 | — | — | WO | disclosed |