Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 6/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4241119 | 0.77 | ACHE (0.41) | ACHETRPV4 | |
| SCHEMBL4239555 | 0.76 | TRPV4 (0.41) | ACHEMAPTSMN1; SMN2KDM4ETRPV4 | |
| SCHEMBL4237345 | 0.71 | KDR (0.40) | ACHEMAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL15688067 | 0.70 | MAPT (0.49) | MAPTSMN1; SMN2KDM4EHPGDCASP1 | |
| SCHEMBL3354387 | 0.66 | ACHE (0.54) | ACHEMAPTSMN1; SMN2HPGDCASP1 | |
| SCHEMBL4236598 | 0.63 | RECQL (0.41) | MAPTSMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL14150651 | 0.62 | ACHE (0.50) | ACHEMAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL4058319 | 0.61 | NPC1 (0.55) | MAPTSMN1; SMN2KDM4ETRPV4NPC1 | |
| SCHEMBL4240553 | 0.60 | NPC1 (0.54) | ACHENAMPTMAPTHPGDNPC1 | |
| SCHEMBL15177819 | 0.60 | RAB9A (0.68) | MAPTSMN1; SMN2KDM4EHPGDCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009010871-A2 | PYRAZOLE DERIVATIVES AS ANTAGONISTS OF ADENOSINE A3 RECEPTOR | ADDEX PHARMA S.A. (CH) | 2009-01-22 | — | — | WO | disclosed |