SCHEMBL4239657

SCHEMBL4239657

NC(=O)c1ccc(O)cc1.O=C(O)N1CCC(Cc2cccc(F)c2)CC1

nearest known ligand 0.55

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
F2 P00734 1/20 0.55
GAA P10253 1/20 0.51
PARP10 Q53GL7 2/20 0.48
MAOB P27338 1/20 0.48
MGLL Q99685 1/20 0.46
GRIN1 Q05586 3/20 0.46
GRIN2B Q13224 3/20 0.46
GRIN2D O15399 2/20 0.46
GRIN3B O60391 2/20 0.46
GRIN2A Q12879 2/20 0.46
GRIN2C Q14957 2/20 0.46
GRIN3A Q8TCU5 2/20 0.46
TNKS O95271 1/20 0.46
PARP1 P09874 1/20 0.46
PARP14 Q460N5 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27670326 0.89 MAOB (0.48) F2GAAPARP10MAOBGRIN1
SCHEMBL4239619 0.87 GAA (0.65) GAAGRIN1GRIN2BGRIN2DGRIN3B
SCHEMBL23365213 0.87 CYP2C9 (0.54) F2
SCHEMBL5180965 0.87 MGLL (0.53) GAAMGLLGRIN1GRIN2BGRIN2D
SCHEMBL4243148 0.86 GAA (0.55) GAAGRIN1GRIN2BGRIN2DGRIN3B
SCHEMBL5320493 0.86 GAA (0.49) F2GAAMGLLGRIN1GRIN2B
SCHEMBL4239736 0.84 MGLL (0.53) GAAMGLL
SCHEMBL4250204 0.84 MGLL (0.54) GAAMGLLGRIN1GRIN2BGRIN2D
SCHEMBL4252210 0.83 HTR2A (0.47) F2GAAGRIN2B
SCHEMBL27943803 0.81 F2 (0.56) F2GRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090170901-A1 Benzoyl Urea Derivatives RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 2009-07-02 US disclosed
EP-1771429-A1 NEW BENZOYL UREA DERIVATIVES RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 2007-04-11 EP disclosed
WO-2006010966-A1 NEW BENZOYL UREA DERIVATIVES Richter Gedeon Vegyészeti Gyár Rt. (HU) 2006-02-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090170901-A1 Benzoyl Urea Derivatives OPRM1, GRIN2C, GRIN3A F2 3090/4885GAA 3604/4885PARP10 3694/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.