⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzylamine SCHEMBL11208558 | 0.97 | LOXL2 (0.88) | — | |
| Benzylamine SCHEMBL5481672 | 0.97 | LOXL2 (1.00) | — | |
| Benzylamine SCHEMBL10707644 | 0.97 | LOXL2 (1.00) | — | |
| Benzylamine SCHEMBL1331207 | 0.97 | — | — | |
| Benzylamine SCHEMBL373 | 0.97 | — | — | |
| SCHEMBL19242392 | 0.97 | LOXL2 (1.00) | — | |
| Benzylamine SCHEMBL23044734 | 0.93 | LOXL2 (0.93) | — | |
| Benzylamine SCHEMBL4306051 | 0.93 | — | — | |
| Benzylamine SCHEMBL1245462 | 0.93 | — | — | |
| Benzylamine SCHEMBL8751247 | 0.93 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 136 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0173522-B1 | PROCESS AND INTERMEDIATES FOR SORBINIL | PFIZER INC. (US) | 1988-12-07 | — | — | EP | claimed |
| US-4704461-A | Processes and intermediates for sorbinil | PFIZER INC. (US) | 1987-11-03 | — | — | US | claimed |
| US-4620019-A | S-6-fluoro-4-aminochroman-4-carboxylic acid derivatives useful as intermediates for sorbinil | PFIZER INC. (US) | 1986-10-28 | — | — | US | claimed |
| US-4607119-A | INSECTICIDES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-08-19 | — | — | US | claimed |
| EP-0173522-A2 | Process and intermediates for sorbinil | PFIZER INC. (US) | 1986-03-05 | — | — | EP | claimed |
| EP-0069033-B1 | HERBICIDAL AMIDE AND ESTER DERIVATIVES OF PYRIDINE, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION | RHONE-POULENC AGROCHIMIE (FR) | 1985-09-04 | — | — | EP | claimed |
| EP-0050074-B1 | METHYL ESTERS OF 2,2-DIMETHYL CYCLOPROPANE-1,3-DICARBOXYLIC ACID, THEIR PREPARATION AND INTERMEDIALES OBTAINED | ROUSSEL-UCLAF (FR) | 1984-07-04 | — | — | EP | claimed |
| EP-0010874-B1 | PROCESS FOR SEPARATING OPTICAL ISOMERS OF SUBSTITUTED CYCLOPROPANE CARBOXYLIC ACIDS; AMINE SALTS OF SUBSTITUTED CYCLOPROPANE CARBOXYLIC ACIDS; A SUBSTITUTED CYCLOPROPANE CARBOXYLIC ACID | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-06-22 | — | — | EP | claimed |
| EP-0068038-A1 | (+)-(4R,6S)-(E)-6-(2-(4'-fluoro-3,3',5-trimethyl-(1,1'-biphenyl)-2-yl)ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one, a process for preparing and a pharmaceutical composition containing the same | MERCK & CO. INC. (US) | 1983-01-05 | — | — | EP | claimed |
| EP-0010874-A1 | Process for separating optical isomers of substituted cyclopropane carboxylic acids; amine salts of substituted cyclopropane carboxylic acids; a substituted cyclopropane carboxylic acid | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1980-05-14 | — | — | EP | claimed |
| EP-3081557-A1 | SALT AND SOLVATES OF A TETRAHYDROISOQUINOLINE DERIVATIVE | Novartis AG (CH) | 2016-10-19 | — | — | EP | disclosed |
| EP-2595960-B1 | SALT AND SOLVATES OF A TETRAHYDROISOQUINOLINE DERIVATIVE | NOVARTIS AG (CH) | 2016-02-24 | — | — | EP | disclosed |
| US-9162985-B2 | Salts and solvates of a tetrahydroisoquinoline derivative | SPINIFEX PHARMACEUTICALS PTY LTD (AU) | 2015-10-20 | — | — | US | disclosed |
| US-20150105422-A1 | SALTS AND SOLVATES OF A TETRAHYDROISOQUINOLINE DERIVATIVE | SPINIFEX PHARMACEUTICALS PTY LTD (AU) | 2015-04-16 | — | — | US | disclosed |
| US-8927575-B2 | Salts and solvates of a tetrahydroisoquinoline derivative | SPINIFEX PHARMACEUTICALS PTY LTD (AU) | 2015-01-06 | — | — | US | disclosed |
| US-3989838-A | Uricosuric compositions and method of producing uricosuria and hypouricemia | SMITHKLINE CORPORATION (US) | 1976-11-02 | — | — | US | disclosed |
| US-3984465-A | DIURETIC, SALURETIC AND URICOSURIC | MERCK & CO., INC. (US) | 1976-10-05 | — | — | US | disclosed |
| US-3965143-A | 16-Oxygenated prostanoic acid derivatives | G. D. SEARLE & CO. (US) | 1976-06-22 | — | — | US | disclosed |
| US-3950406-A | BRONCHODILATORS, HYPOTENSIVE, ANTIULCER | AMERICAN CYANAMID COMPANY (US) | 1976-04-13 | — | — | US | disclosed |
| US-3932519-A | 7,7A-Dihydro-4-[2-(3-alkoxyphenyl)-2-hydroxyethyl]-7a-alkyl-1, 5(6H)-indandiones,3,4,8,8a-tetrahydro-5-[2-(3-alkoxyphenyl)-2-hydroxyethyl]-8a-alkyl-1,6(7H)-naphthalenediones and processes for the preparation thereof utilizing asymmetric induction | HOFFMANN-LA ROCHE INC. (US) | 1976-01-13 | — | — | US | disclosed |