Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.45 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.41 |
| ▸ | TRPC7 | Q9HCX4 | 3/20 | 0.41 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4241218 | 0.80 | MAPK13 (0.54) | MAPK13CYP2C9MAPK11TRPC3TRPC7 | |
| SCHEMBL4246284 | 0.77 | MAPK13 (0.44) | MAPK13CYP2C9MAPK11TRPC3TRPC7 | |
| SCHEMBL4243655 | 0.77 | MAPK13 (0.48) | MAPK13CYP2C9MAPK11TRPC3TRPC7 | |
| SCHEMBL4246294 | 0.76 | MAPK11 (0.55) | MAPK13CYP2C9MAPK11ALDH1A1HDAC6 | |
| SCHEMBL4243526 | 0.76 | MAPK13 (0.48) | MAPK13CYP2C9MAPK11TRPC3TRPC7 | |
| SCHEMBL4245202 | 0.75 | MAPK13 (0.53) | MAPK13CYP2C9MAPK11ALDH1A1KDM4E | |
| SCHEMBL4240989 | 0.74 | MAPK13 (0.50) | MAPK13CYP2C9MAPK11 | |
| SCHEMBL5812295 | 0.74 | MAPK13 (0.53) | MAPK13CYP2C9MAPK11ALDH1A1HSD17B10 | |
| SCHEMBL4246031 | 0.73 | MAPK13 (0.49) | MAPK13CYP2C9MAPK11ALDH1A1KDM4E | |
| SCHEMBL4760873 | 0.73 | MAPK13 (0.49) | MAPK13CYP2C9MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042856-A1 | PYRIDAZINONE DERIVATIVES USED FOR THE TREATMENT OF PAIN | ASTELLAS PHARMA INC (JP) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042856-A1 | PYRIDAZINONE DERIVATIVES USED FOR THE TREATMENT OF PAIN | HRH2, OPRD1, HRH4 | MAPK13 1439/4885CYP2C9 359/4885MAPK11 1195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.