Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 19/20 | 0.69 |
| ▸ | ITGB3 | P05106 | 18/20 | 0.69 |
| ▸ | ITGB1 | P05556 | 7/20 | 0.69 |
| ▸ | ITGA5 | P08648 | 6/20 | 0.69 |
| ▸ | ITGB6 | P18564 | 9/20 | 0.59 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.59 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4067320 | 0.93 | ITGAV (0.59) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL4200668 | 0.84 | ITGB3 (0.65) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL4786884 | 0.83 | ITGB3 (0.71) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL4245277 | 0.82 | ITGAV (0.85) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL4241327 | 0.82 | ITGAV (1.00) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL6729630 | 0.79 | ITGAV (0.59) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL4248670 | 0.79 | ITGAV (0.90) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL4245157 | 0.79 | ITGB1 (0.90) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL26687063 | 0.79 | ITGAV (0.90) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL19953686 | 0.78 | ITGAV (0.75) | ITGAVITGB3ITGB1ITGA5ITGB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049490-A1 | N-(BENZOYL)-O- [2- (PYRIDIN- 2 -YLAMINO) ETHYL]-L-TYROSINE DERIVATIVES AND RELATED COMPOUNDS AS A5B1 ANTAGONISTS FOR THE TREATMENT OF SOLID TUMORS | Astra Zeneca AB (SE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2007141473-A1 | N-(BENZOYL)-O- [2- (PYRIDIN- 2 -YLAMINO) ETHYL] -L-TYROSINE DERIVATIVES AND RELATED COMPOUNDS AS A5B1 ANTAGONISTS FOR THE TREATMENT OF SOLID TUMORS | ASTRAZENECA AB (SE) | 2007-12-13 | — | — | WO | disclosed |