Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 4/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | POLA1 | P09884 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | OXTR | P30559 | 1/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12119299 | 0.93 | KMT2A (0.38) | GAAPOLA1HDAC1KMT2AOXTR | |
| SCHEMBL4241494 | 0.90 | KEAP1 (0.36) | KEAP1NFE2L2GAAPOLA1HDAC1 | |
| SCHEMBL1322546 | 0.89 | GAA (0.43) | KEAP1NFE2L2GAAPOLA1HDAC1 | |
| SCHEMBL1319769 | 0.88 | GAA (0.42) | KEAP1NFE2L2GAAPOLA1HDAC1 | |
| SCHEMBL1110201 | 0.86 | POLA1 (0.36) | KEAP1NFE2L2GAAPOLA1HDAC1 | |
| SCHEMBL12119699 | 0.86 | RORC (0.42) | KMT2ARORC | |
| SCHEMBL1321342 | 0.86 | HDAC2 (0.41) | KEAP1NFE2L2GAAPOLA1HDAC1 | |
| SCHEMBL1318917 | 0.85 | HDAC2 (0.42) | KEAP1NFE2L2GAAPOLA1HDAC1 | |
| SCHEMBL12119239 | 0.85 | EPHX2 (0.38) | GAAPOLA1HDAC1KMT2ARORC | |
| SCHEMBL1319261 | 0.85 | HTT (0.45) | KEAP1NFE2L2GAAPOLA1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009127723-A1 | NEW ARYLSULPHONYLGLYCINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-10-22 | — | — | WO | disclosed |