Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 18/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 18/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4238356 | 0.80 | KEAP1 (0.54) | KEAP1NFE2L2 | |
| SCHEMBL2098098 | 0.80 | HPGD (0.32) | S1PR1L3MBTL1 | |
| SCHEMBL4242197 | 0.80 | KEAP1 (0.41) | KEAP1NFE2L2S1PR1L3MBTL1 | |
| SCHEMBL1110275 | 0.79 | KEAP1 (0.63) | KEAP1NFE2L2 | |
| SCHEMBL1110375 | 0.79 | MMP13 (0.39) | S1PR1 | |
| SCHEMBL1110639 | 0.76 | KEAP1 (0.45) | KEAP1NFE2L2 | |
| SCHEMBL4236968 | 0.75 | KEAP1 (0.40) | KEAP1NFE2L2S1PR1L3MBTL1 | |
| SCHEMBL1110834 | 0.74 | KEAP1 (0.57) | KEAP1NFE2L2 | |
| SCHEMBL4240479 | 0.74 | KEAP1 (0.39) | KEAP1NFE2L2S1PR1L3MBTL1 | |
| SCHEMBL1110582 | 0.73 | KEAP1 (0.41) | KEAP1NFE2L2S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009127723-A1 | NEW ARYLSULPHONYLGLYCINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-10-22 | — | — | WO | disclosed |