Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | COMT | P21964 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | METAP1 | P53582 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxyquinoline SCHEMBL29365411 | 0.67 | TSHR (1.00) | METAP2MMP2CHRM1TSHRCOMT | |
| Oxyquinoline SCHEMBL29716519 | 0.67 | TSHR (1.00) | METAP2MMP2CHRM1TSHRCOMT | |
| Oxyquinoline SCHEMBL37189 | 0.67 | TSHR (1.00) | METAP2MMP2CHRM1TSHRCOMT | |
| Oxyquinoline SCHEMBL253313 | 0.67 | TSHR (1.00) | METAP2MMP2CHRM1TSHRCOMT | |
| Oxyquinoline SCHEMBL23522696 | 0.66 | TSHR (0.95) | METAP2MMP2CHRM1TSHRCOMT | |
| Oxyquinoline SCHEMBL22466317 | 0.66 | TSHR (0.95) | METAP2MMP2CHRM1TSHRCOMT | |
| Oxyquinoline SCHEMBL21195162 | 0.66 | TSHR (0.95) | METAP2MMP2CHRM1TSHRCOMT | |
| Oxyquinoline SCHEMBL20703753 | 0.66 | TSHR (0.95) | METAP2MMP2CHRM1TSHRCOMT | |
| Oxyquinoline SCHEMBL22467701 | 0.66 | TSHR (0.95) | METAP2MMP2CHRM1TSHRCOMT | |
| Oxyquinoline SCHEMBL21875199 | 0.66 | TSHR (0.95) | METAP2MMP2CHRM1TSHRCOMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737831-A4 | NEUROLOGICALLY-ACTIVE COMPOUNDS | PRANA BIOTECHNOLOGY LTD (AU) | 2009-07-22 | — | — | EP | disclosed |
| EP-1737831-A1 | NEUROLOGICALLY-ACTIVE COMPOUNDS | Prana Biotechnology Limited (AU) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005095360-A1 | NEUROLOGICALLY-ACTIVE COMPOUNDS | PRANA BIOTECHNOLOGY LIMITED (AU) | 2005-10-13 | — | — | WO | disclosed |