Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 9/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | MMP15 | P51511 | 1/20 | 0.33 |
| ▸ | MMP16 | P51512 | 1/20 | 0.33 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13878848 | 0.87 | CA1 (0.33) | ESR1ESR2CA1CA2CA9 | |
| SCHEMBL4248773 | 0.83 | PPARD (0.39) | ESR1ESR2HDAC6HDAC1 | |
| SCHEMBL983323 | 0.74 | CA1 (0.47) | CA1CA2CA9CA14 | |
| SCHEMBL985863 | 0.73 | CA1 (0.55) | CA1CA2CA9CA14TAS2R14 | |
| SCHEMBL988054 | 0.72 | CA1 (0.50) | CA1CA2CA9CA14TAS2R14 | |
| SCHEMBL986105 | 0.72 | DRD1 (0.52) | CA1CA2CA9CA14TAS2R14 | |
| SCHEMBL987586 | 0.71 | CA1 (0.49) | CA1CA2CA9CA14 | |
| SCHEMBL985919 | 0.70 | PDE4D (0.45) | CA1CA2CA9CA14 | |
| SCHEMBL986126 | 0.69 | CA1 (0.55) | CA1CA2CA9CA14TAS2R14 | |
| SCHEMBL985708 | 0.68 | DRD1 (0.48) | CA1CA2CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099133-A1 | Isoquinolines Derivatives as Igf-1R Inhibitors | ANALYTECON S.A. (CH) | 2009-04-16 | — | — | US | disclosed |
| EP-1940796-A1 | ISOQUINOLINES DERIVATIVES AS IGF-1R INHIBITORS | Analytecon S.A. (CH) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007029107-A1 | ISOQUINOLINES DERIVATIVES AS IGF-1R INHIBITORS | ANALYTECON SA (CH) | 2007-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099133-A1 | Isoquinolines Derivatives as Igf-1R Inhibitors | IGF1R, IGFBP1, IGF2BP1 | ESR1 1295/4885ESR2 290/4885CA1 4832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.