Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 13/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | GSR | P00390 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6672132 | 0.87 | NOS2 (0.34) | HCAR2KDR | |
| SCHEMBL3206132 | 0.75 | GSR (0.53) | HCAR2KMT2ATSHRKDRGSR | |
| SCHEMBL7044505 | 0.74 | CDK2 (0.55) | KMT2A | |
| SCHEMBL2171482 | 0.72 | KDM4E (0.59) | HCAR2KMT2AKDRGSRKDM4E | |
| SCHEMBL13061 | 0.71 | NOTUM (0.46) | HCAR2LMNA | |
| SCHEMBL3517436 | 0.71 | HCAR2 (0.43) | HCAR2KMT2ATSHRGSRKDM4E | |
| SCHEMBL8136875 | 0.70 | CCNA2 (0.41) | KMT2ALMNA | |
| SCHEMBL28577870 | 0.66 | NPC1 (0.42) | HCAR2KMT2ATSHRGSRKDM4E | |
| SCHEMBL18222126 | 0.65 | CDK5 (0.36) | KDM4EALDH1A1HSD17B10 | |
| SCHEMBL3747850 | 0.65 | ALDH1A1 (0.44) | HCAR2KMT2AKDRGSRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038280-A2 | FUSED, TRICYCLIC SULFONAMIDE INHIBITORS OF GAMMA SECRETASE | Elan Pharmaceuticals Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007143523-A2 | FUSED, TRICYCLIC SULFONAMIDE INHIBITORS OF GAMMA SECRETASE | ELAN PHARMACEUTICALS, INC. (US) | 2007-12-13 | — | — | WO | disclosed |