Sugi Predict

Sugi Predict / Compounds / SCHEMBL4242878

SCHEMBL4242878

SCHEMBL4242878

Cc1nc2[nH]ccc2cc1Br

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 1/20 0.44
▸ LMNA P02545 1/20 0.44
▸ HPGD P15428 1/20 0.44
▸ APOBEC3G Q9HC16 1/20 0.44
▸ CSNK2A1 P68400 2/20 0.40
▸ PRKCI P41743 1/20 0.37
▸ PIK3CA P42336 2/20 0.37
▸ AXL P30530 2/20 0.37
▸ CDK8 P49336 2/20 0.37
▸ MAPK1 P28482 1/20 0.36
▸ PIK3CD O00329 1/20 0.36
▸ PIK3CB P42338 1/20 0.36
▸ PIK3CG P48736 1/20 0.36
▸ AHR P35869 2/20 0.35
▸ CYP2A6 P11509 1/20 0.35
▸ NR4A2 P43354 1/20 0.35
▸ NUDT1 P36639 1/20 0.35
▸ RIPK1 Q13546 1/20 0.35
▸ BRD4 O60885 2/20 0.35
▸ ADORA2A P29274 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11286572 0.79 AXL (0.39) CSNK2A1PRKCIPIK3CAAXLCDK8
SCHEMBL18129582 0.76 CSNK2A1 (0.40) CSNK2A1PRKCIPIK3CAAXLCDK8
SCHEMBL18012904 0.76 GPR84 (0.45) PIK3CAAXLCDK8PIK3CDPIK3CB
SCHEMBL1565481 0.76 CSNK2A1 (0.48) CSNK2A1PRKCIPIK3CAAXLCDK8
SCHEMBL1565089 0.76 AXL (0.41) CSNK2A1PRKCIPIK3CAAXLCDK8
SCHEMBL25346767 0.76 BRD4 (0.42) CSNK2A1PRKCIPIK3CAAXLCDK8
SCHEMBL16246983 0.76 CDK8 (0.40) ALDH1A1PIK3CAAXLCDK8PIK3CD
SCHEMBL25613029 0.74 FEN1 (0.39) CSNK2A1PIK3CAAXLCDK8PIK3CD
SCHEMBL19820203 0.73 KLKB1 (0.43) CSNK2A1PIK3CAAXLCDK8PIK3CD
SCHEMBL12146427 0.73 CDK8 (0.36) CSNK2A1PIK3CAAXLCDK8PIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250051329-A1 BCL-2 INHIBITORS NEWAVE PHARMACEUTICAL INC (US) 2025-02-13 — — US disclosed
US-12220419-B2 BCL-2 inhibitors NEWAVE PHARMACEUTICAL INC. (US) 2025-02-11 — — US disclosed
EP-4387965-A2 ARYL SULFONYL COMPOUNDS AS CCR6 INHIBITORS ChemoCentryx, Inc. (US) 2024-06-26 — — EP disclosed
US-12018016-B2 Aryl sulfonyl (hydroxy) piperidines as CCR6 inhibitors AMGEN INC. (US) 2024-06-25 — — US disclosed
US-12012403-B2 Aryl sulfonyl compounds as CCR6 inhibitors CHEMOCENTRYX, INC. (US) 2024-06-18 — — US disclosed
CN-118019735-A Arylsulfonyl compounds as CCR6 inhibitors 坎莫森特里克斯公司 2024-05-10 — — CN disclosed
CN-117813086-A Arylsulfonyl (hydroxy) piperidines as CCR6 inhibitors 坎莫森特里克斯公司 2024-04-02 — — CN disclosed
US-20230391752-A1 PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AND RELATED USES CHULALONGKORN UNIVERSITY (TH) 2023-12-07 — — US disclosed
US-20230133406-A1 Aryl Sulfonyl (Hydroxy) Piperidines as CCR6 Inhibitors CHEMOCENTRYX, INC. 2023-05-04 — — US disclosed
US-20230125684-A1 Aryl Sulfonyl Compounds as CCR6 Inhibitors CHEMOCENTRYX, INC. 2023-04-27 — — US disclosed
US-20190040062-A1 BCL-2 INHIBITORS NEWAVE PHARMACEUTICAL INC. 2019-02-07 — — US disclosed
WO-2018154133-A1 [1,2,4]-TRIAZOLO [1,5-A]-PYRIMIDINYL DERIVATIVES SUBSTITUTED WITH PIPERIDINE, MORPHOLINE OR PIPERAZINE AS OGA INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2018-08-30 — — WO disclosed
WO-2017132474-A1 BCL-2 INHIBITORS NEWAVE PHARMACEUTICAL INC. (US) 2017-08-03 — — WO disclosed
WO-2017132474-A1 BCL-2 INHIBITORS NEWAVE PHARMACEUTICAL INC. (US) 2017-08-03 — — WO disclosed
EP-3089746-A1 THERAPEUTIC INHIBITORY COMPOUNDS Lifesci Pharmaceuticals, Inc. (BB) 2016-11-09 — — EP disclosed
WO-2015103317-A1 THERAPEUTIC INHIBITORY COMPOUNDS LIFESCI PHARMACEUTICALS, INC. (BB) 2015-07-09 — — WO disclosed
WO-2015103317-A1 THERAPEUTIC INHIBITORY COMPOUNDS LIFESCI PHARMACEUTICALS, INC. (BB) 2015-07-09 — — WO disclosed
US-20090306126-A1 Indole Derivatives ASTRAZENECA AB (SE) 2009-12-10 — — US disclosed
EP-2029593-A1 INDOLE DERIVATIVES AstraZeneca AB (SE) 2009-03-04 — — EP disclosed
WO-2007135398-A1 INDOLE DERIVATIVES ASTRAZENECA AB (SE) 2007-11-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230133406-A1 Aryl Sulfonyl (Hydroxy) Piperidines as CCR6 Inhibitors CCR6, CCR1, CCR4 ALDH1A1 700/4885LMNA 4086/4885HPGD 2932/4885
US-12018016-B2 Aryl sulfonyl (hydroxy) piperidines as CCR6 inhibitors CCR6, CCR1, CCR4 ALDH1A1 700/4885LMNA 4086/4885HPGD 2932/4885
US-20230391752-A1 PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AND RELATED USES GLS2, PYGL, CPS1 ALDH1A1 433/4885LMNA 1941/4885HPGD 377/4885
US-12012403-B2 Aryl sulfonyl compounds as CCR6 inhibitors CCR6, CCR1, CCR3 ALDH1A1 604/4885LMNA 4517/4885HPGD 3708/4885
US-12220419-B2 BCL-2 inhibitors BCL2L10, BCL2, BCL2L11 ALDH1A1 3743/4885LMNA 2803/4885HPGD 913/4885
US-20230125684-A1 Aryl Sulfonyl Compounds as CCR6 Inhibitors CCR6, CCR1, CCR3 ALDH1A1 604/4885LMNA 4517/4885HPGD 3708/4885
US-20250051329-A1 BCL-2 INHIBITORS BCL2L1, BCL2, BCL2A1 ALDH1A1 2239/4885LMNA 762/4885HPGD 2977/4885
US-20190040062-A1 BCL-2 INHIBITORS BCL2L1, BCL2, BCL2A1 ALDH1A1 2239/4885LMNA 762/4885HPGD 2977/4885
US-20090306126-A1 Indole Derivatives MTOR, IDO1, AKT1S1 ALDH1A1 1318/4885LMNA 3520/4885HPGD 1133/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.