Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.63 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.51 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.50 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30716388 | 0.98 | BCAT2 (0.61) | BCAT2PDK2PKN1PKN2NPC1 | |
| SCHEMBL29131435 | 0.91 | BCAT2 (0.53) | BCAT2PDK2PKN1PKN2NPC1 | |
| SCHEMBL31227976 | 0.84 | BCAT2 (0.67) | BCAT2PKN1PKN2PARP1MKNK1 | |
| SCHEMBL167082 | 0.84 | BCAT2 (0.67) | BCAT2PKN1PKN2PARP1MKNK1 | |
| SCHEMBL30514275 | 0.84 | BCAT2 (0.67) | BCAT2PKN1PKN2PARP1MKNK1 | |
| SCHEMBL13734618 | 0.83 | ERN1 (0.51) | BCAT2NPC1RAB9AARKDM4E | |
| Hydrochloric Acid SCHEMBL27890957 | 0.82 | BCAT2 (0.65) | BCAT2PKN1PKN2PARP1MKNK1 | |
| Hydrochloric Acid SCHEMBL30165666 | 0.82 | BCAT2 (0.65) | BCAT2PKN1PKN2PARP1MKNK1 | |
| SCHEMBL30482280 | 0.81 | BCAT2 (0.63) | BCAT2NPC1RAB9ACSNK1A1TYRO3 | |
| SCHEMBL5878337 | 0.80 | BCAT2 (0.87) | BCAT2NPC1RAB9ACSNK1A1TYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101472902-A | Novel piperazine compounds and their use as HCV polymerase inhibitors | JAPAN TOBACCO INC (JP) | 2009-07-01 | — | — | CN | claimed |
| WO-2023246867-A1 | NAV1.8 INHIBITOR | 武汉人福创新药物研发中心有限公司 | 2023-12-28 | — | — | WO | disclosed |
| CN-117263856-A | Nav1.8 inhibitors | 武汉人福创新药物研发中心有限公司 | 2023-12-22 | — | — | CN | disclosed |
| US-20230116770-A1 | SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2023-04-13 | — | — | US | disclosed |
| US-11452717-B2 | Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof | Sanford Burnham Prebys Medical Discovery Institute (US) | 2022-09-27 | — | — | US | disclosed |
| EP-3568390-A1 | SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2019-11-20 | — | — | EP | disclosed |
| CN-108884098-A | 2- amino-N- [7- methoxyl group -2,3- glyoxalidine simultaneously [1,2-c] quinazoline -5- base] pyrimidine -5- benzamide type | 拜耳制药股份公司 | 2018-11-23 | — | — | CN | disclosed |
| CN-108884098-A | 2- amino-N- [7- methoxyl group -2,3- glyoxalidine simultaneously [1,2-c] quinazoline -5- base] pyrimidine -5- benzamide type | 拜耳制药股份公司 | 2018-11-23 | — | — | CN | disclosed |
| WO-2018132372-A1 | SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2018-07-19 | — | — | WO | disclosed |
| EP-3334727-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES | H. Hoffnabb-La Roche Ag (CH) | 2018-06-20 | — | — | EP | disclosed |
| CN-104487434-A | Bicyclic substituted pyrimidine compounds | XUANZHU PHARMA CO LTD | 2015-04-01 | — | — | CN | disclosed |
| CN-104230911-A | 2, 6-diamino- pyrimidin- 5-yl-carboxamides compounds as SYK or JAK kinases inhibitors | PORTOLA PHARM INC | 2014-12-24 | — | — | CN | disclosed |
| CN-102066339-B | 2, 6-diamino-pyrimidin-5-yl-carboxamides as SYK or JAK protein kinase inhibitors | PORTOLA PHARM INC | 2014-09-24 | — | — | CN | disclosed |
| CN-103917526-A | Pyrimidine carboxamide derivatives | APAC PHARMACEUTICAL LLC | 2014-07-09 | — | — | CN | disclosed |
| CN-102066340-B | 2, 6-diamino-pyrimidin- 5-yl-carboxamides as SRK or JAK kinases inhibitors | PORTOLA PHARM INC | 2014-05-14 | — | — | CN | disclosed |
| CN-102066340-A | 2, 6-diamino-pyrimidin- 5-yl-carboxamides as SRK or JAK kinases inhibitors | PORTOLA PHARM INC | 2011-05-18 | — | — | CN | disclosed |
| CN-102066339-A | 2, 6-diamino-pyrimidin-5-yl-carboxamides as SYK or JAK protein kinase inhibitors | PORTOLA PHARM INC | 2011-05-18 | — | — | CN | disclosed |
| WO-2009123986-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-08 | — | — | WO | disclosed |
| CN-101472902-A | Novel piperazine compounds and their use as HCV polymerase inhibitors | JAPAN TOBACCO INC (JP) | 2009-07-01 | — | — | CN | disclosed |
| CN-1038450-A | The 5-pyrimidine carboxamide analog derivative that replaces | UNIROYAL CHEM CO INC (US) | 1990-01-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11452717-B2 | Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof | NAMPT, NAPRT, NNT | BCAT2 532/4885PDK2 653/4885PKN1 2420/4885 |
| US-20230116770-A1 | SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF | NAMPT, NAPRT, NNT | BCAT2 532/4885PDK2 653/4885PKN1 2420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.