Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 11/20 | 0.55 |
| ▸ | CA2 | P00918 | 11/20 | 0.55 |
| ▸ | CA12 | O43570 | 7/20 | 0.55 |
| ▸ | CA7 | P43166 | 3/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.55 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 7/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | PNMT | P11086 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | TDP2 | O95551 | 1/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | HK1 | P19367 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7135031 | 0.89 | CA1 (0.66) | CA1CA2CA12CA7CA14 | |
| SCHEMBL29649377 | 0.89 | CA1 (0.66) | CA1CA2CA12CA7CA14 | |
| SCHEMBL4235756 | 0.85 | CASP1 (0.56) | CA1CA2CA12CA7CA14 | |
| SCHEMBL30232456 | 0.85 | CASP1 (0.56) | CA1CA2CA12CA7CA14 | |
| SCHEMBL1003926 | 0.81 | PBRM1 (0.52) | PBRM1PNMTCASP1CASP7HSD17B10 | |
| SCHEMBL6205829 | 0.81 | PBRM1 (0.52) | CA1CA2CA12CA7CA14 | |
| Hydrochloric Acid SCHEMBL28058141 | 0.80 | PBRM1 (0.55) | CA1CA2CA12CA7CA14 | |
| SCHEMBL8870208 | 0.77 | PBRM1 (0.47) | PBRM1ALDH1A1PNMTPOLBCASP1 | |
| SCHEMBL29649370 | 0.75 | CA1 (0.66) | CA1CA2CA12CA7CA14 | |
| SCHEMBL20638456 | 0.75 | CA1 (0.66) | CA1CA2CA12CA7CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118323-A1 | ANTITUMOR BENZOYLSULFONAMIDES | MADER MARY MARGARET | 2009-05-07 | — | — | US | disclosed |
| EP-1565438-B1 | ANTITUMOR BENZOYLSULFONAMIDES | LILLY CO ELI (US) | 2007-10-17 | — | — | EP | disclosed |
| US-7282595-B2 | Antitumor benzoylsulfonamides | ELI LILLY AND COMPANY (US) | 2007-10-16 | — | — | US | disclosed |
| US-20060106053-A1 | Antitumor benzoylsulfonamides | ELI LILLY AND COMPANY | 2006-05-18 | — | — | US | disclosed |
| EP-1565438-A1 | ANTITUMOR BENZOYLSULFONAMIDES | ELI LILLY AND COMPANY (US) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004048329-A1 | ANTITUMOR BENZOYLSULFONAMIDES | ELI LILLY AND COMPANY (US) | 2004-06-10 | — | — | WO | disclosed |
| EP-0508586-B1 | Substituted indenyl compounds | FGN INC (US) | 1995-05-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118323-A1 | ANTITUMOR BENZOYLSULFONAMIDES | HCCS, GLS2, GLS | CA1 428/4885CA2 1594/4885CA12 122/4885 |
| US-20060106053-A1 | Antitumor benzoylsulfonamides | HCCS, GLS2, GLS | CA1 428/4885CA2 1594/4885CA12 122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.