Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetaminophen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | MB | P02144 | 1/20 | 0.49 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.49 |
| ▸ | CA3 | P07451 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | RARG | P13631 | 1/20 | 0.49 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demannose SCHEMBL17910243 | 0.85 | ALDH1A1 (0.54) | MEN1KMT2AMAPTTSHRALDH1A1 | |
| SCHEMBL13430949 | 0.80 | MPI (0.36) | MEN1KMT2AMAPTALDH1A1CYP3A4 | |
| SCHEMBL215097 | 0.80 | MPI (0.36) | MEN1KMT2AMAPTALDH1A1CYP3A4 | |
| SCHEMBL426315 | 0.80 | MPI (0.36) | MEN1KMT2AMAPTALDH1A1CYP3A4 | |
| SCHEMBL2884877 | 0.80 | MPI (0.36) | MEN1KMT2AMAPTALDH1A1CYP3A4 | |
| Glucuronic Acid SCHEMBL28015551 | 0.78 | MAPT (0.56) | MEN1KMT2AMAPTTSHRALDH1A1 | |
| SCHEMBL426347 | 0.75 | KMT2A (0.51) | MEN1KMT2AMAPTTSHRALDH1A1 | |
| SCHEMBL7070578 | 0.75 | MPI (0.37) | MEN1KMT2AMAPTALDH1A1CYP3A4 | |
| SCHEMBL7066959 | 0.75 | MPI (0.37) | MEN1KMT2AMAPTALDH1A1CYP3A4 | |
| SCHEMBL7068623 | 0.75 | MPI (0.37) | MEN1KMT2AMAPTALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8722864-B2 | Glycosylated acetaminophen pro-drug analogs | NuTek Pharma Ltd. (US) | 2014-05-13 | — | — | US | disclosed |
| US-20130217640-A1 | GLYCOSYLATED ACETAMINOPHEN PRO-DRUG | NuTek Pharma Ltd. | 2013-08-22 | — | — | US | disclosed |
| US-20120022012-A1 | Glycosylated Acetaminophen Pro-Drug Analogs | NuTek Pharma Ltd. | 2012-01-26 | — | — | US | disclosed |
| WO-2012012339-A2 | GLYCOSYLATED ACETAMINOPHEN PRO-DRUG ANALOGS | NuTek Pharma Ltd. (US) | 2012-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022012-A1 | Glycosylated Acetaminophen Pro-Drug Analogs | UGT1A3, GCG, UGT1A1 | MEN1 4056/4885KMT2A 4128/4885MAPT 2243/4885 |
| US-20130217640-A1 | GLYCOSYLATED ACETAMINOPHEN PRO-DRUG | UGT1A3, GCG, UGGT1 | MEN1 4207/4885KMT2A 4023/4885MAPT 1994/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.