Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.47 |
| ▸ | PRKCA | P17252 | 2/20 | 0.47 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 4/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 2/20 | 0.44 |
| ▸ | AGER | Q15109 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13911400 | 0.86 | EGFR (0.49) | EGFRAIMP2PRKCDROCK2PRKACA | |
| SCHEMBL7052367 | 0.83 | AGER (0.66) | EGFRAIMP2PRKCDROCK2PRKACA | |
| SCHEMBL2115684 | 0.77 | ABL1 (0.62) | PRKCDROCK1PRKCASYKABL1 | |
| SCHEMBL30847380 | 0.75 | CDK2 (0.55) | EGFRPRKCDPRKACADYRK1APIK3CG | |
| SCHEMBL27111928 | 0.75 | CDK2 (0.55) | EGFRPRKCDPRKACADYRK1APIK3CG | |
| SCHEMBL14344221 | 0.74 | SYK (0.47) | EGFRPRKCDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL14368039 | 0.74 | CDK5 (0.53) | EGFRPRKCDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL3439832 | 0.73 | SYK (0.64) | PRKCDPIK3CGPRKCASYKABL1 | |
| SCHEMBL857880 | 0.73 | AURKA (0.70) | EGFRPRKCDROCK1PRKCAABL1 | |
| SCHEMBL2064243 | 0.72 | ROCK1 (0.56) | EGFRAIMP2PRKCDROCK2PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069360-A1 | Organic Compounds | CARAVATTI, GIORGIO (CH) | 2009-03-12 | — | — | US | disclosed |
| US-20090069360-A1 | Organic Compounds | CARAVATTI, GIORGIO (CH) | 2009-03-12 | — | — | US | disclosed |
| US-20090069360-A1 | Organic Compounds | CARAVATTI, GIORGIO (CH) | 2009-03-12 | — | — | US | disclosed |
| EP-2001864-A1 | HETEROCYCLIC ORGANIC COMPOUNDS FOR THE TREATMENT OF IN PARTICULAR MELANOMA | Novartis Pharma AG (CH) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007109045-A1 | HETEROCYCLIC ORGANIC COMPOUNDS FOR THE TREATMENT OF IN PARTICULAR MELANOMA | NOVARTIS AG (CH) | 2007-09-27 | — | — | WO | disclosed |
| WO-2007109045-A1 | HETEROCYCLIC ORGANIC COMPOUNDS FOR THE TREATMENT OF IN PARTICULAR MELANOMA | NOVARTIS AG (CH) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069360-A1 | Organic Compounds | BRAF, MAP3K1, RAF1 | EGFR 169/4885AIMP2 3401/4885PRKCD 1634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.