Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER | Q15109 | 1/20 | 0.66 |
| ▸ | SRC | P12931 | 4/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.55 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.55 |
| ▸ | YES1 | P07947 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 3/20 | 0.50 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.47 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | PRKACA | P17612 | 2/20 | 0.45 |
| ▸ | MET | P08581 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | WEE1 | P30291 | 2/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7052995 | 0.86 | AGER (0.60) | AGERSRCFGFR1FGFR2FGFR4 | |
| SCHEMBL4244136 | 0.83 | EGFR (0.53) | AGERSRCEGFRAIMP2MAP3K5 | |
| SCHEMBL7466120 | 0.83 | AGER (0.67) | AGERSRCFGFR1FGFR2FGFR4 | |
| SCHEMBL7464616 | 0.81 | ABL1 (0.68) | AGERSRCEGFRABL1PRKACA | |
| SCHEMBL7464949 | 0.81 | AGER (0.59) | AGERSRCFGFR1FGFR2FGFR4 | |
| SCHEMBL13924608 | 0.80 | SYK (0.66) | AGERSRCFGFR1FGFR2FGFR4 | |
| SCHEMBL7057161 | 0.80 | KDR (0.47) | AGEREGFRABL1KDRIGF1R | |
| SCHEMBL7660259 | 0.79 | AGER (0.55) | AGERSRCFGFR1FGFR2FGFR4 | |
| SCHEMBL18304247 | 0.79 | AGER (1.00) | AGERSRCFGFR1FGFR2FGFR4 | |
| SCHEMBL1736474 | 0.78 | AGER (0.60) | AGERSRCFGFR1FGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003026666-A1 | 2-PHENYLAMINO-4- (5-PYRAZOLYLAMINO)-PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS, IN PARTICULAR, AS SRC KINASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |