Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL28200478 | 0.86 | LMNA (0.58) | POLBKMT2ATDP1LMNAALDH1A1 | |
| SCHEMBL4244228 | 0.84 | KMT2A (0.53) | POLBKMT2ACYP19A1KDM4ECYP17A1 | |
| SCHEMBL5621133 | 0.81 | CYP19A1 (0.50) | POLBKMT2ACYP19A1KDM4ECYP17A1 | |
| SCHEMBL3292568 | 0.81 | ALDH1A1 (0.64) | POLBKMT2ACYP19A1KDM4ECYP17A1 | |
| SCHEMBL112785 | 0.81 | CYP19A1 (0.50) | POLBKMT2ACYP19A1KDM4ECYP17A1 | |
| SCHEMBL2945515 | 0.81 | ALDH1A1 (0.64) | POLBKMT2ACYP19A1KDM4ECYP17A1 | |
| SCHEMBL28997377 | 0.81 | POLB (0.53) | POLBKMT2ACYP19A1KDM4ECYP17A1 | |
| SCHEMBL28997380 | 0.80 | POLB (0.53) | POLBKMT2ACYP19A1KDM4ECYP17A1 | |
| SCHEMBL30001820 | 0.79 | ALDH1A1 (0.68) | KMT2ATDP1LMNAALDH1A1MAPK1 | |
| SCHEMBL78553 | 0.79 | ALDH1A1 (0.68) | KMT2ATDP1LMNAALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147221-A1 | SMALL MOLECULE LEPTIN RECEPTOR MODULATORS | BIOVITRUM AB (PUBL) (SE) | 2009-12-10 | — | — | WO | disclosed |
| WO-2009147216-A1 | NEW PYRIDINE DERIVATIVES AS LEPTIN RECEPTOR MODULATOR MIMETICS | BIOVITRUM AB (PUBL) (SE) | 2009-12-10 | — | — | WO | disclosed |
| WO-2009147211-A1 | NEW COMPOUNDS V | BIOVITRUM AB (PUBL) (SE) | 2009-12-10 | — | — | WO | disclosed |