Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27953632 | 0.82 | POLB (0.44) | USP2ALDH1A1CYP1A2CYP3A4TSHR | |
| SCHEMBL18894258 | 0.80 | MTOR (0.38) | — | |
| SCHEMBL15564472 | 0.71 | ALDH1A1 (0.34) | USP2ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2725269 | 0.68 | CYP1A2 (0.34) | USP2ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL369828 | 0.68 | CYP1A2 (0.33) | USP2ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2726529 | 0.67 | PDE10A (0.37) | USP2ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL27656894 | 0.66 | KDM4E (0.39) | USP2ALDH1A1CYP1A2CYP3A4TSHR | |
| SCHEMBL27830972 | 0.64 | SORD (0.31) | — | |
| SCHEMBL28323315 | 0.64 | GAA (0.43) | TSHRMAPK1 | |
| SCHEMBL18894290 | 0.62 | PIK3CD (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046799-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Genentech, Inc. (US) | 2009-04-15 | — | — | EP | disclosed |
| WO-2007127183-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GENENTECH, INC. (US) | 2007-11-08 | — | — | WO | disclosed |