Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9427400 | 0.77 | MAOA (0.41) | ALDH1A1CYP2D6CYP2C9ALOX15MAPK1 | |
| SCHEMBL8279051 | 0.76 | MAOA (0.41) | ALDH1A1CYP2D6CYP2C9ALOX15MAPK1 | |
| SCHEMBL7442533 | 0.75 | CYP2D6 (0.49) | ALDH1A1CYP2D6CYP2C9ALOX15MAPK1 | |
| SCHEMBL3149281 | 0.75 | ALDH1A1 (0.49) | ALDH1A1CYP2D6CYP2C9ALOX15MAPK1 | |
| SCHEMBL10926721 | 0.75 | CYP3A4 (0.48) | ALDH1A1CYP2D6CYP2C9ALOX15MAPK1 | |
| SCHEMBL3153882 | 0.75 | ALDH1A1 (0.49) | ALDH1A1CYP2D6CYP2C9ALOX15MAPK1 | |
| SCHEMBL4247806 | 0.72 | CYP2D6 (0.46) | ALDH1A1CYP2D6CYP2C9ALOX15MAPK1 | |
| SCHEMBL1073016 | 0.72 | ALDH1A1 (0.46) | ALDH1A1CYP2D6CYP2C9ALOX15MAPK1 | |
| SCHEMBL27736487 | 0.72 | ALDH1A1 (0.46) | ALDH1A1CYP2D6CYP2C9ALOX15MAPK1 | |
| SCHEMBL31028051 | 0.71 | NQO2 (0.52) | CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101386594-B | 1,2,4, 5-tetrahydro-3H-benzazepine compounds, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB | 2012-05-16 | — | — | CN | disclosed |
| US-8076325-B2 | 1,2,4,5-tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2011-12-13 | — | — | US | disclosed |
| WO-2009066041-A2 | DERIVATIVES OF 1,2,4,5-TETRAHYDRO-3H-BENZAZEPINES, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2009-05-28 | — | — | WO | disclosed |
| CN-101386594-A | 1,2,4, 5-tetrahydro-3H-benzoaza compounds, a process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2009-03-18 | — | — | CN | disclosed |
| US-20090069296-A1 | 1,2,4,5-Tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2009-03-12 | — | — | US | disclosed |
| US-5296482-A | (Benzocycloalkyl) alkylamines | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069296-A1 | 1,2,4,5-Tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them | OXER1, NR1H3, OXSR1 | ALDH1A1 1056/4885CYP2D6 82/4885CYP2C9 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.