Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MPI | P34949 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3344245 | 0.84 | ACHE (0.61) | KMT2ALMNAACHESLC6A3KDM4E | |
| SCHEMBL2608042 | 0.84 | ACHE (0.54) | KMT2AALDH1A1MAPTACHE | |
| SCHEMBL18799364 | 0.84 | ACHE (0.54) | KMT2AALDH1A1MAPTACHE | |
| SCHEMBL4243250 | 0.82 | ALDH1A1 (0.43) | KMT2AALDH1A1LMNAACHESLC6A2 | |
| SCHEMBL4246710 | 0.82 | NPC1 (0.52) | ACHE | |
| SCHEMBL11493352 | 0.78 | ALDH1A1 (0.46) | TSHRKMT2AALDH1A1LMNAMAPT | |
| SCHEMBL3045356 | 0.75 | HSP90AA1 (0.50) | TSHRKMT2AALDH1A1LMNAMAPT | |
| SCHEMBL11486227 | 0.75 | ALDH1A1 (0.52) | TSHRALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL4048996 | 0.74 | GAA (0.47) | ALDH1A1ACHEKDM4ESMN1; SMN2 | |
| SCHEMBL11496145 | 0.73 | ALDH1A1 (0.50) | TSHRKMT2AALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049118-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | SmithKline Beecham Corporation (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008011551-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-24 | — | — | WO | disclosed |