Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 14/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4245630 | 0.94 | KIF11 (0.41) | KIF11ALDH1A1MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL4255915 | 0.94 | KIF11 (0.40) | KIF11ALDH1A1TDP1MAP1LC3BCYP3A4 | |
| SCHEMBL4252370 | 0.92 | KIF11 (0.37) | KIF11ALDH1A1TDP1KMT2AMAP1LC3B | |
| SCHEMBL4255875 | 0.91 | PTGDR2 (0.41) | KIF11ALDH1A1KMT2AMC4R | |
| SCHEMBL4255895 | 0.90 | KIF11 (0.36) | KIF11ALDH1A1 | |
| SCHEMBL4251314 | 0.89 | KIF11 (0.36) | KIF11ALDH1A1TDP1MAPT | |
| SCHEMBL4249156 | 0.89 | KIF11 (0.40) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL4055441 | 0.79 | KIF11 (0.42) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL4245135 | 0.79 | KIF11 (0.52) | KIF11 | |
| SCHEMBL4245137 | 0.79 | KIF11 (0.45) | KIF11ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035426-A1 | PYRAZOLOPYRIMIDONES | 4SC AG (DE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007144384-A1 | PYRAZOLOPYRIMIDONES | 4SC AG (DE) | 2007-12-21 | — | — | WO | disclosed |